AGAP6 [The Human Chemical-Genetic Interaction Map Project]

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======= AGAP6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AGAP6
  * **<color #00a2e8>Official Name</color>**: ArfGAP with GTPase domain, ankyrin repeat and PH domain 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=414189|414189]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5VW22|Q5VW22]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AGAP6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AGAP6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621157|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Putative GTPase-activating protein. {ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ArfGap|
|Ank 2|
|Ank|
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GTPase activator activity|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|positive regulation of hydrolase activity|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.8|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.72|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.79|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.79|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 103/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|6/28|
|bone|1/26|
|breast|4/33|
|central nervous system|5/56|
|cervix|2/4|
|colorectal|2/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|3/21|
|liver|3/20|
|lung|14/75|
|lymphocyte|5/16|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|5/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2578
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AGAP6 Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>