AGMO [The Human Chemical-Genetic Interaction Map Project]

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======= AGMO =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AGMO
  * **<color #00a2e8>Official Name</color>**: alkylglycerol monooxygenase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=392636|392636]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZNB7|Q6ZNB7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AGMO&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AGMO|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613738|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes. {ECO:0000269|PubMed:20643956}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FA hydroxylase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glyceryl-ether monooxygenase activity|
|ether lipid metabolic process|
|glycerol ether metabolic process|
|ether metabolic process|
|triglyceride biosynthetic process|
|neutral lipid biosynthetic process|
|acylglycerol biosynthetic process|
|triglyceride metabolic process|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|iron ion binding|
|membrane lipid metabolic process|
|glycerolipid biosynthetic process|
|glycerolipid metabolic process|
|lipid biosynthetic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|endoplasmic reticulum|
|lipid metabolic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.74|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.79|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.11|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.22|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.35|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.94|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.99|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|3.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9327
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AGMO Expression in NALM6 Cells: 0.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>