AGPAT1 [The Human Chemical-Genetic Interaction Map Project]

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======= AGPAT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AGPAT1
  * **<color #00a2e8>Official Name</color>**: 1-acylglycerol-3-phosphate O-acyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10554|10554]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99943|Q99943]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AGPAT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AGPAT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603099|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. {ECO:0000269|PubMed:21873652}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Acyltransferase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CDP-diacylglycerol biosynthetic process|
|CDP-diacylglycerol metabolic process|
|1-acylglycerol-3-phosphate O-acyltransferase activity|
|phosphatidic acid biosynthetic process|
|phosphatidic acid metabolic process|
|pyrimidine nucleotide biosynthetic process|
|positive regulation of cytokine-mediated signaling pathway|
|pyrimidine-containing compound biosynthetic process|
|positive regulation of response to cytokine stimulus|
|pyrimidine nucleotide metabolic process|
|pyrimidine-containing compound metabolic process|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|nucleotide biosynthetic process|
|phospholipid biosynthetic process|
|nucleoside phosphate biosynthetic process|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|nucleotide metabolic process|
|positive regulation of cytokine production|
|nucleoside phosphate metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|regulation of cytokine production|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|endoplasmic reticulum|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.69|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-2.17|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-2.14|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-2.11|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.06|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-2.06|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.01|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.98|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.77|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.77|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.72|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.75|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.79|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.81|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.81|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.84|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.9|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.06|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.12|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.21|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.29|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.48|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.5|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.8|
|[[:results:exp518|RK-33 8μM R08 exp518]]|5.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:acsl4|ACSL4]]|0.461|
|[[:human genes:h:hsd17b12|HSD17B12]]|0.407|
|[[:human genes:p:pex6|PEX6]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3190
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AGPAT1 Expression in NALM6 Cells: 4.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>