AGPAT6 [The Human Chemical-Genetic Interaction Map Project]

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======= AGPAT6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPAT4
  * **<color #00a2e8>Official Name</color>**: glycerol-3-phosphate acyltransferase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=137964|137964]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86UL3|Q86UL3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AGPAT6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AGPAT6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608143|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs. {ECO:0000269|PubMed:18238778}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Acyltransferase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glandular epithelial cell maturation|
|sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity|
|glycerol-3-phosphate O-acyltransferase activity|
|columnar/cuboidal epithelial cell maturation|
|CDP-diacylglycerol biosynthetic process|
|CDP-diacylglycerol metabolic process|
|epithelial cell maturation|
|1-acylglycerol-3-phosphate O-acyltransferase activity|
|glandular epithelial cell development|
|triglyceride biosynthetic process|
|diacylglycerol metabolic process|
|neutral lipid biosynthetic process|
|acylglycerol biosynthetic process|
|phosphatidylcholine biosynthetic process|
|glandular epithelial cell differentiation|
|phosphatidic acid biosynthetic process|
|phosphatidic acid metabolic process|
|lactation|
|pyrimidine nucleotide biosynthetic process|
|columnar/cuboidal epithelial cell development|
|pyrimidine-containing compound biosynthetic process|
|pyrimidine nucleotide metabolic process|
|regulation of multicellular organism growth|
|body fluid secretion|
|triglyceride metabolic process|
|phosphatidylcholine metabolic process|
|columnar/cuboidal epithelial cell differentiation|
|thioester metabolic process|
|acyl-CoA metabolic process|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|pyrimidine-containing compound metabolic process|
|mammary gland development|
|purine nucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|anatomical structure maturation|
|cell maturation|
|epithelial cell development|
|ammonium ion metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|developmental maturation|
|nucleotide biosynthetic process|
|phospholipid biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|glycerophospholipid metabolic process|
|purine ribonucleotide metabolic process|
|fatty acid metabolic process|
|ribonucleotide metabolic process|
|regulation of developmental growth|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|gland development|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|regulation of body fluid levels|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|regulation of growth|
|epithelial cell differentiation|
|cellular amide metabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|endoplasmic reticulum|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cell development|
|small molecule metabolic process|
|tissue development|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-2.95|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-2.62|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-2.28|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-2.1|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.92|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-1.86|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.85|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.84|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.82|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-1.8|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.8|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.77|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-1.75|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.7|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.7|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.7|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.7|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.72|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.74|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.87|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|3.09|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|6.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chp1|CHP1]]|0.596|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18491
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AGPAT6 Expression in NALM6 Cells: 6.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>