AGR2 [The Human Chemical-Genetic Interaction Map Project]

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======= AGR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AGR2
  * **<color #00a2e8>Official Name</color>**: anterior gradient 2, protein disulphide isomerase family member
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10551|10551]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95994|O95994]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AGR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AGR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606358|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113). {ECO:0000250, ECO:0000269|PubMed:18199544, ECO:0000269|PubMed:23274113}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lung goblet cell differentiation|
|positive regulation of PERK-mediated unfolded protein response|
|lobar bronchus epithelium development|
|mucus secretion|
|lobar bronchus development|
|positive regulation of IRE1-mediated unfolded protein response|
|lung secretory cell differentiation|
|regulation of PERK-mediated unfolded protein response|
|bronchus development|
|dystroglycan binding|
|regulation of IRE1-mediated unfolded protein response|
|positive regulation of endoplasmic reticulum unfolded protein response|
|secretion by tissue|
|lung epithelial cell differentiation|
|lung cell differentiation|
|regulation of endoplasmic reticulum unfolded protein response|
|lung epithelium development|
|positive regulation of epidermal growth factor receptor signaling pathway|
|epidermal growth factor receptor binding|
|positive regulation of ERBB signaling pathway|
|positive regulation of response to endoplasmic reticulum stress|
|glandular epithelial cell differentiation|
|digestive tract morphogenesis|
|positive regulation of protein localization to plasma membrane|
|positive regulation of protein localization to cell periphery|
|carbohydrate derivative transport|
|body fluid secretion|
|regulation of response to endoplasmic reticulum stress|
|regulation of epidermal growth factor receptor signaling pathway|
|regulation of ERBB signaling pathway|
|regulation of protein localization to plasma membrane|
|columnar/cuboidal epithelial cell differentiation|
|regulation of protein localization to cell periphery|
|positive regulation of cell-substrate adhesion|
|positive regulation of protein localization to membrane|
|digestive tract development|
|digestive system development|
|lung development|
|positive regulation of developmental growth|
|respiratory tube development|
|regulation of protein localization to membrane|
|respiratory system development|
|regulation of cell-substrate adhesion|
|response to endoplasmic reticulum stress|
|positive regulation of growth|
|positive regulation of cellular protein localization|
|regulation of developmental growth|
|positive regulation of cell adhesion|
|regulation of body fluid levels|
|regulation of cellular protein localization|
|tube morphogenesis|
|regulation of growth|
|regulation of cell adhesion|
|epithelial cell differentiation|
|regulation of cellular response to stress|
|tube development|
|protein homodimerization activity|
|regulation of cellular localization|
|negative regulation of cell death|
|endoplasmic reticulum|
|regulation of protein localization|
|epithelium development|
|secretion|
|positive regulation of developmental process|
|regulation of response to stress|
|extracellular space|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.06|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.24|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.39|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10632
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AGR2 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>