AHCTF1 [The Human Chemical-Genetic Interaction Map Project]

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======= AHCTF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AHCTF1
  * **<color #00a2e8>Official Name</color>**: AT-hook containing transcription factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25909|25909]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WYP5|Q8WYP5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AHCTF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AHCTF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610853|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear pore complex assembly|
|nuclear pore outer ring|
|nuclear pore organization|
|pore complex assembly|
|nuclear pore|
|condensed chromosome kinetochore|
|regulation of cytokinesis|
|nuclear matrix|
|chromatin|
|nucleus organization|
|mRNA transport|
|regulation of cell division|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|RNA localization|
|nuclear membrane|
|nucleobase-containing compound transport|
|cell division|
|regulation of cell cycle process|
|cellular protein-containing complex assembly|
|regulation of cell cycle|
|cell cycle|
|DNA binding|
|protein transport|
|peptide transport|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|amide transport|
|establishment of protein localization|
|nitrogen compound transport|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.27|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-2.22|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-2.09|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.04|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.95|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.82|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.75|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.73|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.7|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.7|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.75|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.8|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.84|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.85|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.86|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.88|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.92|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|2.06|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|2.21|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.21|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.22|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|2.32|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cdc73|CDC73]]|0.54|
|[[:human genes:v:vasn|VASN]]|0.52|
|[[:human genes:p:psma6|PSMA6]]|0.518|
|[[:human genes:n:ndc1|NDC1]]|0.506|
|[[:human genes:d:dtl|DTL]]|0.505|
|[[:human genes:s:snrpa1|SNRPA1]]|0.484|
|[[:human genes:s:ssh2|SSH2]]|0.479|
|[[:human genes:s:s1pr4|S1PR4]]|0.471|
|[[:human genes:p:psmb4|PSMB4]]|0.468|
|[[:human genes:p:psmb1|PSMB1]]|0.466|
|[[:human genes:p:psmd3|PSMD3]]|0.465|
|[[:human genes:p:psmd1|PSMD1]]|0.464|
|[[:human genes:r:rps28|RPS28]]|0.463|
|[[:human genes:z:zfand5|ZFAND5]]|0.461|
|[[:human genes:n:nup160|NUP160]]|0.459|
|[[:human genes:i:ints5|INTS5]]|0.458|
|[[:human genes:k:kpnb1|KPNB1]]|0.458|
|[[:human genes:p:psmd11|PSMD11]]|0.456|
|[[:human genes:a:aaas|AAAS]]|0.455|
|[[:human genes:p:psmb2|PSMB2]]|0.455|
|[[:human genes:r:rps9|RPS9]]|0.453|
|[[:human genes:n:narfl|NARFL]]|0.452|
|[[:human genes:a:acsf2|ACSF2]]|0.451|
|[[:human genes:c:c14orf93|C14orf93]]|0.449|
|[[:human genes:t:ttyh1|TTYH1]]|0.447|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.446|
|[[:human genes:a:akirin2|AKIRIN2]]|0.444|
|[[:human genes:p:prpf3|PRPF3]]|0.442|
|[[:human genes:m:myo1h|MYO1H]]|0.441|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.44|
|[[:human genes:p:psmd2|PSMD2]]|0.44|
|[[:human genes:n:nupl1|NUPL1]]|0.438|
|[[:human genes:m:med17|MED17]]|0.438|
|[[:human genes:n:nup85|NUP85]]|0.436|
|[[:human genes:n:nup54|NUP54]]|0.434|
|[[:human genes:m:mt1e|MT1E]]|0.434|
|[[:human genes:d:ddtl|DDTL]]|0.433|
|[[:human genes:k:kctd17|KCTD17]]|0.433|
|[[:human genes:t:tfip11|TFIP11]]|0.432|
|[[:human genes:r:rpsa|RPSA]]|0.432|
|[[:human genes:s:sf3b3|SF3B3]]|0.43|
|[[:human genes:t:twistnb|TWISTNB]]|0.429|
|[[:human genes:g:golga8h|GOLGA8H]]|0.429|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.429|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.428|
|[[:human genes:g:golga8j|GOLGA8J]]|0.428|
|[[:human genes:c:chmp2a|CHMP2A]]|0.427|
|[[:human genes:n:nup153|NUP153]]|0.427|
|[[:human genes:g:gltscr2|GLTSCR2]]|0.427|
|[[:human genes:p:plk1|PLK1]]|0.426|
|[[:human genes:r:rpl35|RPL35]]|0.426|
|[[:human genes:s:smg7|SMG7]]|0.425|
|[[:human genes:r:rps2|RPS2]]|0.424|
|[[:human genes:t:tceb3c|TCEB3C]]|0.424|
|[[:human genes:c:cdca3|CDCA3]]|0.424|
|[[:human genes:p:psma7|PSMA7]]|0.424|
|[[:human genes:r:rps12|RPS12]]|0.423|
|[[:human genes:r:rrp15|RRP15]]|0.422|
|[[:human genes:s:supt6h|SUPT6H]]|0.422|
|[[:human genes:g:golga8k|GOLGA8K]]|0.42|
|[[:human genes:e:elmod3|ELMOD3]]|0.42|
|[[:human genes:p:psmd7|PSMD7]]|0.419|
|[[:human genes:s:sec13|SEC13]]|0.419|
|[[:human genes:r:rfc1|RFC1]]|0.419|
|[[:human genes:c:cbwd5|CBWD5]]|0.418|
|[[:human genes:p:polr2f|POLR2F]]|0.417|
|[[:human genes:c:cdc6|CDC6]]|0.417|
|[[:human genes:r:rbm39|RBM39]]|0.417|
|[[:human genes:r:rrp7a|RRP7A]]|0.417|
|[[:human genes:p:psmc6|PSMC6]]|0.417|
|[[:human genes:p:psmd14|PSMD14]]|0.417|
|[[:human genes:r:rrn3|RRN3]]|0.416|
|[[:human genes:s:slc38a7|SLC38A7]]|0.415|
|[[:human genes:p:pola2|POLA2]]|0.415|
|[[:human genes:c:cwc22|CWC22]]|0.413|
|[[:human genes:r:riok2|RIOK2]]|0.411|
|[[:human genes:g:gprin2|GPRIN2]]|0.41|
|[[:human genes:r:ranbp2|RANBP2]]|0.41|
|[[:human genes:z:znf830|ZNF830]]|0.41|
|[[:human genes:c:cbwd3|CBWD3]]|0.409|
|[[:human genes:n:nup43|NUP43]]|0.408|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.408|
|[[:human genes:t:trim52|TRIM52]]|0.407|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.406|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.406|
|[[:human genes:r:rps5|RPS5]]|0.405|
|[[:human genes:c:ccna2|CCNA2]]|0.405|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.404|
|[[:human genes:r:rad51|RAD51]]|0.402|
|[[:human genes:p:pwp2|PWP2]]|0.402|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.401|
|[[:human genes:a:aqr|AQR]]|0.401|
|[[:human genes:c:cdc45|CDC45]]|0.401|
|[[:human genes:p:pole|POLE]]|0.401|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.401|
|[[:human genes:i:igfn1|IGFN1]]|0.4|
|[[:human genes:t:timeless|TIMELESS]]|0.4|
|[[:human genes:a:atp13a1|ATP13A1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 451/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|18/28|
|blood|22/28|
|bone|15/26|
|breast|20/33|
|central nervous system|30/56|
|cervix|2/4|
|colorectal|12/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|9/16|
|kidney|10/21|
|liver|7/20|
|lung|53/75|
|lymphocyte|12/16|
|ovary|13/26|
|pancreas|17/24|
|peripheral nervous system|12/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|11/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|8/22|
|urinary tract|12/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 994
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AHCTF1 Expression in NALM6 Cells: 7.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>