AHR [The Human Chemical-Genetic Interaction Map Project]

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======= AHR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AHR
  * **<color #00a2e8>Official Name</color>**: aryl hydrocarbon receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=196|196]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35869|P35869]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AHR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AHR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600253|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. {ECO:0000269|PubMed:10395741, ECO:0000269|PubMed:7961644}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAS|
|PAS 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytosolic aryl hydrocarbon receptor complex|
|cellular response to 2,3,7,8-tetrachlorodibenzodioxine|
|response to 2,3,7,8-tetrachlorodibenzodioxine|
|response to forskolin|
|TFIID-class transcription factor complex binding|
|cellular response to forskolin|
|response to platelet aggregation inhibitor|
|sequence-specific double-stranded DNA binding|
|enhancer binding|
|transcription coactivator binding|
|TBP-class protein binding|
|Hsp90 protein binding|
|nuclear receptor activity|
|E-box binding|
|cellular response to cAMP|
|regulation of B cell proliferation|
|circadian regulation of gene expression|
|cellular response to alcohol|
|cellular response to ketone|
|response to cAMP|
|cellular response to antibiotic|
|xenobiotic metabolic process|
|response to organophosphorus|
|circadian rhythm|
|cAMP-mediated signaling|
|response to purine-containing compound|
|protein dimerization activity|
|intracellular receptor signaling pathway|
|cyclic-nucleotide-mediated signaling|
|cellular response to xenobiotic stimulus|
|response to ketone|
|transcription factor complex|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|transcription regulatory region DNA binding|
|regulation of leukocyte proliferation|
|response to alcohol|
|rhythmic process|
|response to xenobiotic stimulus|
|response to antibiotic|
|transcription factor binding|
|second-messenger-mediated signaling|
|cellular response to drug|
|transcription by RNA polymerase II|
|blood vessel development|
|protein heterodimerization activity|
|response to toxic substance|
|vasculature development|
|regulation of lymphocyte activation|
|cardiovascular system development|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|protein-containing complex|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|regulation of cell activation|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cellular response to nitrogen compound|
|DNA-binding transcription factor activity|
|response to lipid|
|circulatory system development|
|protein homodimerization activity|
|response to organic cyclic compound|
|apoptotic process|
|response to organonitrogen compound|
|response to drug|
|programmed cell death|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell death|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|intracellular signal transduction|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.94|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-1.78|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.15|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.2|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.21|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15021
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AHR Expression in NALM6 Cells: 1.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>