AK9 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= AK9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AK9
  * **<color #00a2e8>Official Name</color>**: adenylate kinase 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=221264|221264]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5TCS8|Q5TCS8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AK9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AK9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615358|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ADK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dGDP phosphorylation|
|dCMP phosphorylation|
|CDP phosphorylation|
|dCDP phosphorylation|
|AMP phosphorylation|
|UDP phosphorylation|
|GDP phosphorylation|
|dAMP phosphorylation|
|CMP phosphorylation|
|dADP phosphorylation|
|TDP phosphorylation|
|purine deoxyribonucleoside triphosphate biosynthetic process|
|dADP metabolic process|
|dGDP metabolic process|
|purine deoxyribonucleoside diphosphate metabolic process|
|nucleoside monophosphate kinase activity|
|deoxyribonucleoside diphosphate metabolic process|
|deoxyribonucleoside triphosphate biosynthetic process|
|purine deoxyribonucleoside triphosphate metabolic process|
|purine deoxyribonucleotide metabolic process|
|AMP metabolic process|
|nucleoside monophosphate phosphorylation|
|deoxyribonucleoside triphosphate metabolic process|
|nucleoside diphosphate kinase activity|
|nucleobase-containing small molecule interconversion|
|2-deoxyribonucleotide metabolic process|
|deoxyribose phosphate metabolic process|
|ATP biosynthetic process|
|deoxyribonucleotide metabolic process|
|purine ribonucleoside monophosphate metabolic process|
|purine nucleoside monophosphate metabolic process|
|ATP generation from ADP|
|purine ribonucleoside triphosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|ADP metabolic process|
|ribonucleoside monophosphate metabolic process|
|ribonucleoside triphosphate biosynthetic process|
|purine ribonucleoside triphosphate metabolic process|
|nucleoside diphosphate phosphorylation|
|purine ribonucleoside diphosphate metabolic process|
|nucleotide phosphorylation|
|purine nucleoside diphosphate metabolic process|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside diphosphate metabolic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|nucleoside monophosphate metabolic process|
|nucleoside diphosphate metabolic process|
|nucleoside triphosphate metabolic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|ATP metabolic process|
|nuclear membrane|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|generation of precursor metabolites and energy|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|drug metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.76|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.7|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.76|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.83|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.88|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.98|
|[[:results:exp136|MS094 2μM R03 exp136]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8363
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AK9 Expression in NALM6 Cells: 3.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>