AKAP8L [The Human Chemical-Genetic Interaction Map Project]

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======= AKAP8L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AKAP8L
  * **<color #00a2e8>Official Name</color>**: A-kinase anchoring protein 8 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26993|26993]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULX6|Q9ULX6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AKAP8L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AKAP8L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609475|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903). {ECO:0000269|PubMed:10748171, ECO:0000269|PubMed:11034899, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11884601, ECO:0000269|PubMed:12538639, ECO:0000269|PubMed:16980585, ECO:0000305|PubMed:10761695}. (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses. {ECO:0000269|PubMed:11402034}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AKAP95|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of mRNA export from nucleus|
|regulation of ribonucleoprotein complex localization|
|DEAD/H-box RNA helicase binding|
|regulation of histone phosphorylation|
|regulation of RNA export from nucleus|
|lamin binding|
|nuclear envelope disassembly|
|membrane disassembly|
|regulation of nucleobase-containing compound transport|
|mitotic chromosome condensation|
|positive regulation of histone deacetylation|
|protein kinase A regulatory subunit binding|
|positive regulation of protein deacetylation|
|regulation of histone deacetylation|
|regulation of protein export from nucleus|
|regulation of protein deacetylation|
|chromosome condensation|
|nuclear envelope organization|
|positive regulation of histone modification|
|PML body|
|positive regulation of chromatin organization|
|regulation of nucleocytoplasmic transport|
|mitotic sister chromatid segregation|
|nuclear matrix|
|histone deacetylase binding|
|chromatin|
|nucleus organization|
|cell cycle G2/M phase transition|
|sister chromatid segregation|
|regulation of histone modification|
|mitotic nuclear division|
|ribonucleoprotein complex|
|positive regulation of chromosome organization|
|DNA packaging|
|regulation of chromatin organization|
|nuclear chromosome segregation|
|regulation of intracellular protein transport|
|chromosome segregation|
|cell cycle phase transition|
|nuclear division|
|DNA conformation change|
|organelle fission|
|regulation of chromosome organization|
|regulation of intracellular transport|
|RNA splicing|
|cellular component disassembly|
|nuclear speck|
|endomembrane system organization|
|mRNA processing|
|regulation of cellular protein localization|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|mitotic cell cycle|
|mRNA metabolic process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|membrane organization|
|RNA processing|
|regulation of cellular localization|
|cell cycle process|
|regulation of protein localization|
|chromosome organization|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|regulation of organelle organization|
|cell cycle|
|RNA binding|
|regulation of protein phosphorylation|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.92|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.9|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.78|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.71|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.76|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17397
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AKAP8L Expression in NALM6 Cells: 6.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>