AKR1B10 [The Human Chemical-Genetic Interaction Map Project]

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======= AKR1B10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AKR1B10
  * **<color #00a2e8>Official Name</color>**: aldo-keto reductase family 1 member B10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57016|57016]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60218|O60218]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AKR1B10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AKR1B10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604707|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. {ECO:0000269|PubMed:18087047}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aldo ket red|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|geranylgeranyl reductase activity|
|farnesol metabolic process|
|sesquiterpenoid catabolic process|
|farnesol catabolic process|
|sesquiterpenoid metabolic process|
|indanol dehydrogenase activity|
|polyprenol catabolic process|
|allyl-alcohol dehydrogenase activity|
|terpenoid catabolic process|
|cellular detoxification of aldehyde|
|polyprenol metabolic process|
|retinal dehydrogenase activity|
|doxorubicin metabolic process|
|polyketide metabolic process|
|isoprenoid catabolic process|
|daunorubicin metabolic process|
|aminoglycoside antibiotic metabolic process|
|cellular response to aldehyde|
|NADP-retinol dehydrogenase activity|
|aldo-keto reductase (NADP) activity|
|alcohol dehydrogenase (NADP+) activity|
|tertiary alcohol metabolic process|
|alditol:NADP+ 1-oxidoreductase activity|
|primary alcohol catabolic process|
|glycoside metabolic process|
|quinone metabolic process|
|retinol metabolic process|
|antibiotic catabolic process|
|secondary metabolic process|
|alcohol catabolic process|
|cellular ketone metabolic process|
|organic hydroxy compound catabolic process|
|primary alcohol metabolic process|
|cellular detoxification|
|retinoid metabolic process|
|antibiotic metabolic process|
|diterpenoid metabolic process|
|oxidoreductase activity|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|detoxification|
|glycosyl compound metabolic process|
|isoprenoid metabolic process|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|hormone metabolic process|
|cellular response to toxic substance|
|lysosome|
|lipid catabolic process|
|alcohol metabolic process|
|small molecule catabolic process|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|drug metabolic process|
|response to toxic substance|
|regulation of hormone levels|
|cellular lipid metabolic process|
|oxidation-reduction process|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|lipid metabolic process|
|mitochondrion|
|response to oxygen-containing compound|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16638
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.41 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AKR1B10 Expression in NALM6 Cells: 0.41'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>