AKR1C4 [The Human Chemical-Genetic Interaction Map Project]

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======= AKR1C4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AKR1C4
  * **<color #00a2e8>Official Name</color>**: aldo-keto reductase family 1 member C4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1109|1109]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17516|P17516]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AKR1C4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AKR1C4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600451|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aldo ket red|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chlordecone reductase activity|
|cellular response to jasmonic acid stimulus|
|response to jasmonic acid|
|androsterone dehydrogenase activity|
|ketosteroid monooxygenase activity|
|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|
|retinal dehydrogenase activity|
|daunorubicin metabolic process|
|polyketide metabolic process|
|doxorubicin metabolic process|
|aminoglycoside antibiotic metabolic process|
|steroid dehydrogenase activity|
|aldo-keto reductase (NADP) activity|
|bile acid transmembrane transporter activity|
|progesterone metabolic process|
|alcohol dehydrogenase (NADP+) activity|
|alditol:NADP+ 1-oxidoreductase activity|
|tertiary alcohol metabolic process|
|glycoside metabolic process|
|androgen metabolic process|
|bile acid biosynthetic process|
|C21-steroid hormone metabolic process|
|bile acid and bile salt transport|
|quinone metabolic process|
|prostaglandin metabolic process|
|prostanoid metabolic process|
|bile acid metabolic process|
|secondary metabolic process|
|cellular ketone metabolic process|
|electron transfer activity|
|primary alcohol metabolic process|
|antibiotic metabolic process|
|retinoid metabolic process|
|unsaturated fatty acid metabolic process|
|diterpenoid metabolic process|
|icosanoid metabolic process|
|oxidoreductase activity|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|steroid biosynthetic process|
|glycosyl compound metabolic process|
|monocarboxylic acid transport|
|isoprenoid metabolic process|
|organic hydroxy compound transport|
|fatty acid derivative metabolic process|
|electron transport chain|
|monocarboxylic acid biosynthetic process|
|organic hydroxy compound biosynthetic process|
|ammonium ion metabolic process|
|hormone metabolic process|
|cellular response to acid chemical|
|steroid metabolic process|
|organic acid transport|
|carboxylic acid transport|
|lipid transport|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|alcohol metabolic process|
|lipid localization|
|fatty acid metabolic process|
|response to acid chemical|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|organic anion transport|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|lipid biosynthetic process|
|anion transport|
|small molecule biosynthetic process|
|cellular response to hormone stimulus|
|carboxylic acid metabolic process|
|response to hormone|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|ion transport|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.73|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.94|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|2.19|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11375
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AKR1C4 Expression in NALM6 Cells: -1.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>