ALDH1A3 [The Human Chemical-Genetic Interaction Map Project]

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======= ALDH1A3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALDH1A3
  * **<color #00a2e8>Official Name</color>**: aldehyde dehydrogenase 1 family member A3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=220|220]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P47895|P47895]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALDH1A3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALDH1A3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600463|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid (PubMed:27759097). Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde (PubMed:27759097). Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region (By similarity). {ECO:0000250|UniProtKB:Q9JHW9, ECO:0000269|PubMed:27759097}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aldedh|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleus accumbens development|
|olfactory pit development|
|Harderian gland development|
|aldehyde dehydrogenase [NAD(P)+] activity|
|righting reflex|
|thyroid hormone binding|
|retinoic acid biosynthetic process|
|retinal dehydrogenase activity|
|optic cup morphogenesis involved in camera-type eye development|
|diterpenoid biosynthetic process|
|embryonic camera-type eye formation|
|aldehyde dehydrogenase (NAD) activity|
|retinal metabolic process|
|terpenoid biosynthetic process|
|nose development|
|NAD+ binding|
|striatum development|
|reflex|
|subpallium development|
|embryonic camera-type eye morphogenesis|
|isoprenoid biosynthetic process|
|retinoic acid metabolic process|
|embryonic eye morphogenesis|
|embryonic camera-type eye development|
|retinol metabolic process|
|face development|
|neuromuscular process controlling balance|
|cellular aldehyde metabolic process|
|neural nucleus development|
|primary alcohol metabolic process|
|protein homotetramerization|
|inner ear morphogenesis|
|retinoid metabolic process|
|neuromuscular process|
|limbic system development|
|diterpenoid metabolic process|
|camera-type eye morphogenesis|
|ear morphogenesis|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|isoprenoid metabolic process|
|morphogenesis of embryonic epithelium|
|eye morphogenesis|
|protein tetramerization|
|monocarboxylic acid biosynthetic process|
|inner ear development|
|locomotory behavior|
|respiratory system development|
|hormone metabolic process|
|ear development|
|sensory organ morphogenesis|
|telencephalon development|
|embryonic organ morphogenesis|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|camera-type eye development|
|alcohol metabolic process|
|protein homooligomerization|
|eye development|
|visual system development|
|sensory system development|
|forebrain development|
|gland development|
|morphogenesis of an epithelium|
|embryonic organ development|
|organic hydroxy compound metabolic process|
|protein complex oligomerization|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|behavior|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|brain development|
|head development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|carboxylic acid metabolic process|
|animal organ morphogenesis|
|cellular lipid metabolic process|
|oxidation-reduction process|
|embryo development|
|central nervous system development|
|oxoacid metabolic process|
|organic acid metabolic process|
|epithelium development|
|lipid metabolic process|
|nervous system process|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell death|
|small molecule metabolic process|
|tissue development|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.91|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.72|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.81|
|[[:results:exp453|B02 10μM R08 exp453]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8214
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALDH1A3 Expression in NALM6 Cells: 0.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>