ALDH1L1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= ALDH1L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALDH1L1
  * **<color #00a2e8>Official Name</color>**: aldehyde dehydrogenase 1 family member L1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10840|10840]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75891|O75891]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALDH1L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALDH1L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600249|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Formyl trans N|
|Formyl trans C|
|Aldedh|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hydroxymethyl-, formyl- and related transferase activity|
|10-formyltetrahydrofolate catabolic process|
|formyltetrahydrofolate dehydrogenase activity|
|folic acid-containing compound catabolic process|
|pteridine-containing compound catabolic process|
|10-formyltetrahydrofolate metabolic process|
|aldehyde dehydrogenase (NAD) activity|
|coenzyme catabolic process|
|dicarboxylic acid catabolic process|
|tetrahydrofolate metabolic process|
|folic acid metabolic process|
|one-carbon metabolic process|
|folic acid-containing compound metabolic process|
|cellular modified amino acid catabolic process|
|pteridine-containing compound metabolic process|
|catalytic activity|
|cofactor catabolic process|
|water-soluble vitamin metabolic process|
|dicarboxylic acid metabolic process|
|vitamin metabolic process|
|cellular modified amino acid metabolic process|
|coenzyme metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|cofactor metabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|drug metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.7|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.73|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.566|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7108
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALDH1L1 Expression in NALM6 Cells: 2.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>