ALOX15B [The Human Chemical-Genetic Interaction Map Project]

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======= ALOX15B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALOX15B
  * **<color #00a2e8>Official Name</color>**: arachidonate 15-lipoxygenase type B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=247|247]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15296|O15296]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALOX15B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALOX15B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603697|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)- HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells. {ECO:0000269|PubMed:10625675, ECO:0000269|PubMed:11839751, ECO:0000269|PubMed:12704195, ECO:0000269|PubMed:16112079, ECO:0000269|PubMed:18067895, ECO:0000269|PubMed:22912809, ECO:0000269|PubMed:24497644}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lipoxygenase|
|PLAT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|arachidonate 8(S)-lipoxygenase activity|
|linoleate 13S-lipoxygenase activity|
|arachidonate 15-lipoxygenase activity|
|hepoxilin biosynthetic process|
|hepoxilin metabolic process|
|positive regulation of peroxisome proliferator activated receptor signaling pathway|
|regulation of peroxisome proliferator activated receptor signaling pathway|
|positive regulation of chemokine secretion|
|lipoxygenase pathway|
|positive regulation of macrophage derived foam cell differentiation|
|regulation of chemokine secretion|
|positive regulation of keratinocyte differentiation|
|linoleic acid metabolic process|
|positive regulation of epidermal cell differentiation|
|regulation of macrophage derived foam cell differentiation|
|long-chain fatty acid biosynthetic process|
|positive regulation of epidermis development|
|regulation of keratinocyte differentiation|
|prostate gland development|
|unsaturated fatty acid biosynthetic process|
|positive regulation of chemokine production|
|arachidonic acid metabolic process|
|positive regulation of epithelial cell differentiation|
|regulation of epidermal cell differentiation|
|extrinsic component of membrane|
|regulation of chemokine production|
|regulation of epidermis development|
|unsaturated fatty acid metabolic process|
|icosanoid metabolic process|
|long-chain fatty acid metabolic process|
|fatty acid biosynthetic process|
|iron ion binding|
|positive regulation of cytokine secretion|
|regulation of epithelial cell differentiation|
|lipid binding|
|fatty acid derivative metabolic process|
|monocarboxylic acid biosynthetic process|
|regulation of cytokine secretion|
|negative regulation of growth|
|negative regulation of cell migration|
|positive regulation of protein secretion|
|negative regulation of cell motility|
|positive regulation of peptide secretion|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|negative regulation of cellular component movement|
|urogenital system development|
|fatty acid metabolic process|
|negative regulation of locomotion|
|cytoskeleton|
|positive regulation of secretion by cell|
|gland development|
|positive regulation of protein transport|
|reproductive structure development|
|reproductive system development|
|positive regulation of secretion|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|monocarboxylic acid metabolic process|
|negative regulation of cell cycle|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|developmental process involved in reproduction|
|regulation of growth|
|negative regulation of cell population proliferation|
|regulation of cytokine production|
|regulation of protein transport|
|calcium ion binding|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of cell migration|
|carboxylic acid metabolic process|
|regulation of cell motility|
|apoptotic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|positive regulation of cell differentiation|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|oxoacid metabolic process|
|organic acid metabolic process|
|regulation of protein localization|
|programmed cell death|
|cell death|
|regulation of cell cycle|
|lipid metabolic process|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.91|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.83|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8057
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALOX15B Expression in NALM6 Cells: -1.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>