ALOX5AP [The Human Chemical-Genetic Interaction Map Project]

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======= ALOX5AP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALOX5AP
  * **<color #00a2e8>Official Name</color>**: arachidonate 5-lipoxygenase activating protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=241|241]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20292|P20292]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALOX5AP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALOX5AP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603700|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. {ECO:0000269|PubMed:2300173, ECO:0000269|PubMed:8440384}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MAPEG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|leukotriene-C4 synthase activity|
|arachidonic acid binding|
|lipoxin biosynthetic process|
|lipoxin metabolic process|
|lipoxygenase pathway|
|leukotriene biosynthetic process|
|glutathione peroxidase activity|
|glutathione transferase activity|
|leukotriene metabolic process|
|protein homotrimerization|
|unsaturated fatty acid biosynthetic process|
|enzyme activator activity|
|icosanoid biosynthetic process|
|protein trimerization|
|cellular response to calcium ion|
|cellular oxidant detoxification|
|fatty acid derivative biosynthetic process|
|cellular detoxification|
|protein N-terminus binding|
|unsaturated fatty acid metabolic process|
|icosanoid metabolic process|
|fatty acid biosynthetic process|
|detoxification|
|response to calcium ion|
|fatty acid derivative metabolic process|
|nuclear envelope|
|monocarboxylic acid biosynthetic process|
|cellular response to metal ion|
|cellular response to toxic substance|
|cellular response to inorganic substance|
|nuclear membrane|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|fatty acid metabolic process|
|protein homooligomerization|
|response to metal ion|
|response to toxic substance|
|protein complex oligomerization|
|monocarboxylic acid metabolic process|
|response to inorganic substance|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|endoplasmic reticulum|
|organic acid metabolic process|
|lipid metabolic process|
|positive regulation of catalytic activity|
|protein-containing complex assembly|
|small molecule metabolic process|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16165
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALOX5AP Expression in NALM6 Cells: 0.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>