AMIGO1 [The Human Chemical-Genetic Interaction Map Project]

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======= AMIGO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AMIGO1
  * **<color #00a2e8>Official Name</color>**: adhesion molecule with Ig like domain 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57463|57463]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86WK6|Q86WK6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AMIGO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AMIGO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615689|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. {ECO:0000250|UniProtKB:Q80ZD7, ECO:0000250|UniProtKB:Q80ZD8}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
|I-set|
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pericellular basket|
|cellular response to L-glutamate|
|response to L-glutamate|
|positive regulation of voltage-gated potassium channel activity|
|axonal fasciculation|
|neuron projection fasciculation|
|positive regulation of potassium ion transmembrane transporter activity|
|neuronal cell body membrane|
|positive regulation of potassium ion transmembrane transport|
|potassium channel regulator activity|
|positive regulation of potassium ion transport|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|neuron recognition|
|regulation of potassium ion transmembrane transporter activity|
|positive regulation of synapse assembly|
|cellular response to nutrient|
|cellular response to amino acid stimulus|
|positive regulation of cation channel activity|
|regulation of potassium ion transmembrane transport|
|voltage-gated potassium channel complex|
|positive regulation of axonogenesis|
|regulation of potassium ion transport|
|positive regulation of ion transmembrane transporter activity|
|regulation of synapse assembly|
|myelination|
|axon ensheathment|
|ensheathment of neurons|
|positive regulation of transporter activity|
|response to amino acid|
|perikaryon|
|positive regulation of cation transmembrane transport|
|positive regulation of ion transmembrane transport|
|positive regulation of cell morphogenesis involved in differentiation|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|regulation of cation channel activity|
|regulation of axonogenesis|
|positive regulation of transmembrane transport|
|cellular response to acid chemical|
|response to nutrient|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|cellular response to nutrient levels|
|cell recognition|
|regulation of ion transmembrane transporter activity|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|cellular response to extracellular stimulus|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|regulation of cation transmembrane transport|
|cellular response to external stimulus|
|response to acid chemical|
|positive regulation of neuron differentiation|
|axonogenesis|
|positive regulation of cell projection organization|
|regulation of metal ion transport|
|cellular response to drug|
|axon development|
|dendrite|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of neurogenesis|
|regulation of ion transmembrane transport|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|response to nutrient levels|
|cell-cell adhesion|
|cell part morphogenesis|
|positive regulation of cellular component biogenesis|
|response to extracellular stimulus|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell morphogenesis involved in differentiation|
|regulation of transmembrane transport|
|cellular response to organonitrogen compound|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|regulation of cell projection organization|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|central nervous system development|
|positive regulation of transport|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of developmental process|
|response to endogenous stimulus|
|generation of neurons|
|response to oxygen-containing compound|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.71|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|1.79|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8008
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AMIGO1 Expression in NALM6 Cells: 1.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>