ANAPC13 [The Human Chemical-Genetic Interaction Map Project]

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======= ANAPC13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANAPC13
  * **<color #00a2e8>Official Name</color>**: anaphase promoting complex subunit 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25847|25847]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BS18|Q9BS18]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANAPC13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANAPC13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614484|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:15060174, ECO:0000269|PubMed:18485873}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Apc13p|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|anaphase-promoting complex|
|protein K11-linked ubiquitination|
|protein polyubiquitination|
|cell division|
|protein ubiquitination|
|protein modification by small protein conjugation|
|protein modification by small protein conjugation or removal|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-3.27|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2.54|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.5|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|-2.39|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.27|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:ube2s|UBE2S]]|0.5|
|[[:human genes:a:anapc15|ANAPC15]]|0.431|
|[[:human genes:s:sgol1|SGOL1]]|0.41|
|[[:human genes:u:ube2c|UBE2C]]|0.408|
|[[:human genes:s:ska1|SKA1]]|0.405|
|[[:human genes:t:tbcd|TBCD]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 105/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|5/28|
|blood|4/28|
|bone|6/26|
|breast|3/33|
|central nervous system|8/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|4/21|
|liver|3/20|
|lung|11/75|
|lymphocyte|2/16|
|ovary|3/26|
|pancreas|1/24|
|peripheral nervous system|5/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|5/22|
|urinary tract|2/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5903
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANAPC13 Expression in NALM6 Cells: 4.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>