ANGPTL3 [The Human Chemical-Genetic Interaction Map Project]

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======= ANGPTL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANGPTL3
  * **<color #00a2e8>Official Name</color>**: angiopoietin like 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27329|27329]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5C1|Q9Y5C1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANGPTL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANGPTL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604774|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism (PubMed:11788823, PubMed:12909640, PubMed:23661675, PubMed:25495645). Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake (By similarity). Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface; the function does not require ANGPTL3 proteolytic cleavage but seems to be mediated by the N-terminal domain, and is not inhibited by GPIHBP1 (PubMed:12097324, PubMed:19318355, PubMed:20581395). Can inhibit endothelial lipase, causing increased plasma levels of high density lipoprotein (HDL) cholesterol and phospholipids (PubMed:17110602, PubMed:19028676). Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol (PubMed:12565906). Suppresses LPL specifically in oxidative tissues which is required to route very low density lipoprotein (VLDL)-TG to white adipose tissue (WAT) for storage in response to food; the function may involve cooperation with circulating, liver-derived ANGPTL8 and ANGPTL4 expression in WAT (By similarity). Contributes to lower plasma levels of low density lipoprotein (LDL)-cholesterol by a mechanism that is independent of the canonical pathway implicating APOE and LDLR. May stimulate hypothalamic LPL activity (By similarity). {ECO:0000250|UniProtKB:Q9R182, ECO:0000269|PubMed:11788823, ECO:0000269|PubMed:12097324, ECO:0000269|PubMed:12565906, ECO:0000269|PubMed:12909640, ECO:0000269|PubMed:17110602, ECO:0000269|PubMed:19028676, ECO:0000269|PubMed:19318355, ECO:0000269|PubMed:20581395, ECO:0000269|PubMed:23661675, ECO:0000269|PubMed:25495645, ECO:0000305|PubMed:20581395}. Involved in angiogenesis. Binds to endothelial cells via integrin alpha-V/beta-3 (ITGAV:ITGB3), activates FAK, MAPK and Akt signaling pathways and induces cell adhesion and cell migration (PubMed:11877390). Secreted from podocytes, may modulate properties of glomerular endothelial cells involving integrin alpha-V/beta-3 and Akt signaling (PubMed:18535744). May increase the motility of podocytes. May induce actin filament rearrangements in podocytes implicating integrin alpha-V/beta-3 and Rac1 activation. Binds to hematopoietic stem cells (HSC) and is involved in the regulation of HSC activity probably implicating down-regulation of IKZF1/IKAROS (By similarity). {ECO:0000250|UniProtKB:Q9R182, ECO:0000269|PubMed:11877390, ECO:0000269|PubMed:18535744}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fibrinogen C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of lipoprotein lipase activity|
|phospholipase inhibitor activity|
|negative regulation of phospholipase activity|
|phospholipid homeostasis|
|negative regulation of lipase activity|
|regulation of lipoprotein lipase activity|
|glycerol metabolic process|
|alditol metabolic process|
|positive regulation of lipid catabolic process|
|lipid storage|
|enzyme inhibitor activity|
|phospholipid catabolic process|
|acylglycerol homeostasis|
|triglyceride homeostasis|
|regulation of lipid catabolic process|
|anion homeostasis|
|artery morphogenesis|
|regulation of phospholipase activity|
|cholesterol homeostasis|
|sterol homeostasis|
|artery development|
|integrin-mediated signaling pathway|
|regulation of lipase activity|
|polyol metabolic process|
|cholesterol metabolic process|
|cell-matrix adhesion|
|organophosphate catabolic process|
|secondary alcohol metabolic process|
|integrin binding|
|lipid homeostasis|
|sterol metabolic process|
|positive regulation of lipid metabolic process|
|growth factor activity|
|positive regulation of angiogenesis|
|maintenance of location|
|cellular carbohydrate metabolic process|
|heparin binding|
|lamellipodium|
|positive regulation of vasculature development|
|cell-substrate adhesion|
|cellular lipid catabolic process|
|early endosome|
|steroid metabolic process|
|regulation of angiogenesis|
|lipid catabolic process|
|angiogenesis|
|alcohol metabolic process|
|lipid localization|
|regulation of vasculature development|
|fatty acid metabolic process|
|phospholipid metabolic process|
|regulation of lipid metabolic process|
|blood vessel morphogenesis|
|positive regulation of catabolic process|
|negative regulation of hydrolase activity|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|blood vessel development|
|positive regulation of cell migration|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|monocarboxylic acid metabolic process|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|cell surface|
|tube morphogenesis|
|ion homeostasis|
|negative regulation of catalytic activity|
|tube development|
|regulation of cell migration|
|circulatory system development|
|organophosphate metabolic process|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|carboxylic acid metabolic process|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|cellular lipid metabolic process|
|regulation of locomotion|
|Golgi apparatus|
|regulation of catabolic process|
|regulation of cellular component movement|
|oxoacid metabolic process|
|organic acid metabolic process|
|regulation of anatomical structure morphogenesis|
|chemical homeostasis|
|negative regulation of molecular function|
|lipid metabolic process|
|regulation of hydrolase activity|
|positive regulation of developmental process|
|response to endogenous stimulus|
|extracellular space|
|homeostatic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18100
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANGPTL3 Expression in NALM6 Cells: -3.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>