ANKRD26 [The Human Chemical-Genetic Interaction Map Project]

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======= ANKRD26 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANKRD26
  * **<color #00a2e8>Official Name</color>**: ankyrin repeat domain 26
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22852|22852]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UPS8|Q9UPS8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANKRD26&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANKRD26|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610855|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein containing N-terminal ankyrin repeats which function in protein-protein interactions. Mutations in this gene are associated with autosomal dominant thrombocytopenia-2. Pseudogenes of this gene are found on chromosome 7, 10, 13 and 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. {ECO:0000250|UniProtKB:Q811D2}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank|
|Ank 2|
|DUF3496|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of fat cell differentiation|
|regulation of fat cell differentiation|
|centrosome|
|negative regulation of cell differentiation|
|negative regulation of developmental process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|1.72|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.78|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.91|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|4.56|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|5.37|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|6.62|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cradd|CRADD]]|0.662|
|[[:human genes:p:pidd|PIDD]]|0.654|
|[[:human genes:c:casp2|CASP2]]|0.652|
|[[:human genes:c:c2cd3|C2CD3]]|0.628|
|[[:human genes:k:kiaa0753|KIAA0753]]|0.598|
|[[:human genes:n:nin|NIN]]|0.583|
|[[:human genes:o:odf2|ODF2]]|0.581|
|[[:human genes:p:pibf1|PIBF1]]|0.572|
|[[:human genes:c:cep128|CEP128]]|0.566|
|[[:human genes:c:cep76|CEP76]]|0.563|
|[[:human genes:c:c16orf59|C16orf59]]|0.548|
|[[:human genes:c:ccdc41|CCDC41]]|0.547|
|[[:human genes:o:ofd1|OFD1]]|0.547|
|[[:human genes:c:c14orf80|C14orf80]]|0.535|
|[[:human genes:f:fopnl|FOPNL]]|0.535|
|[[:human genes:c:cep120|CEP120]]|0.513|
|[[:human genes:t:tubd1|TUBD1]]|0.485|
|[[:human genes:s:sclt1|SCLT1]]|0.473|
|[[:human genes:c:cep78|CEP78]]|0.471|
|[[:human genes:t:tube1|TUBE1]]|0.457|
|[[:human genes:h:hyls1|HYLS1]]|0.447|
|[[:human genes:c:cep152|CEP152]]|0.432|
|[[:human genes:r:rttn|RTTN]]|0.429|
|[[:human genes:c:cep44|CEP44]]|0.423|
|[[:human genes:p:ppp1r35|PPP1R35]]|0.416|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5778
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANKRD26 Expression in NALM6 Cells: 5.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>