ANLN [The Human Chemical-Genetic Interaction Map Project]

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======= ANLN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANLN
  * **<color #00a2e8>Official Name</color>**: anillin actin binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54443|54443]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQW6|Q9NQW6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANLN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANLN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616027|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|septin ring assembly|
|positive regulation of bleb assembly|
|protein localization to actin cytoskeleton|
|protein localization to cell division site|
|protein localization to actomyosin contractile ring|
|protein localization to mitotic actomyosin contractile ring|
|septin ring organization|
|regulation of bleb assembly|
|septin cytoskeleton organization|
|glomerular visceral epithelial cell migration|
|actomyosin contractile ring|
|protein localization to cell cortex|
|actomyosin contractile ring assembly|
|assembly of actomyosin apparatus involved in cytokinesis|
|actomyosin contractile ring organization|
|bleb|
|cell cortex region|
|regulation of exit from mitosis|
|GTP-Rho binding|
|cytokinetic process|
|protein localization to cytoskeleton|
|cortical actin cytoskeleton organization|
|cortical cytoskeleton organization|
|mitotic cytokinesis|
|epithelial cell migration|
|hematopoietic progenitor cell differentiation|
|epithelium migration|
|tissue migration|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|positive regulation of plasma membrane bounded cell projection assembly|
|actomyosin structure organization|
|midbody|
|regulation of mitotic nuclear division|
|ameboidal-type cell migration|
|regulation of nuclear division|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|actin cytoskeleton|
|protein localization to cell periphery|
|actin binding|
|cadherin binding|
|positive regulation of cell projection organization|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|cell division|
|actin cytoskeleton organization|
|positive regulation of cellular component biogenesis|
|hemopoiesis|
|actin filament-based process|
|mitotic cell cycle process|
|hematopoietic or lymphoid organ development|
|regulation of mitotic cell cycle|
|immune system development|
|mitotic cell cycle|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|protein localization to organelle|
|regulation of cell cycle process|
|organelle assembly|
|cellular protein-containing complex assembly|
|regulation of cellular component biogenesis|
|cell migration|
|cell cycle process|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|locomotion|
|cell cycle|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.77|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.8|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.25|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 41/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|1/26|
|breast|4/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|1/20|
|lung|4/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1841
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANLN Expression in NALM6 Cells: 6.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>