ANO9 [The Human Chemical-Genetic Interaction Map Project]

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======= ANO9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANO9
  * **<color #00a2e8>Official Name</color>**: anoctamin 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=338440|338440]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A1A5B4|A1A5B4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANO9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANO9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619963|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the TMEM16 (anoctamin) family of proteins, some of which form integral membrane calcium-activated chloride channels. The function of the encoded protein has yet to be elucidated, although it may have channel-forming abilities and also may have phospholipid scramblase activity. This gene has been observed to be upregulated in stage II and III colorectal cancers. [provided by RefSeq, Dec 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium- activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. {ECO:0000250|UniProtKB:P86044, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Anoctamin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of intracellular calcium activated chloride channel activity|
|negative regulation of inorganic anion transmembrane transport|
|negative regulation of chloride transport|
|regulation of intracellular calcium activated chloride channel activity|
|calcium activated phosphatidylserine scrambling|
|negative regulation of anion channel activity|
|calcium activated phospholipid scrambling|
|calcium activated phosphatidylcholine scrambling|
|calcium activated galactosylceramide scrambling|
|regulation of inorganic anion transmembrane transport|
|regulation of chloride transport|
|regulation of anion channel activity|
|phospholipid scramblase activity|
|negative regulation of anion transmembrane transport|
|intracellular calcium activated chloride channel activity|
|plasma membrane phospholipid scrambling|
|regulation of anion transmembrane transport|
|negative regulation of anion transport|
|phospholipid translocation|
|lipid translocation|
|regulation of membrane lipid distribution|
|negative regulation of ion transmembrane transporter activity|
|negative regulation of transporter activity|
|phospholipid transport|
|plasma membrane organization|
|regulation of anion transport|
|negative regulation of ion transmembrane transport|
|chloride transport|
|negative regulation of transmembrane transport|
|organophosphate ester transport|
|negative regulation of ion transport|
|inorganic anion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|lipid transport|
|lipid localization|
|endomembrane system organization|
|organic anion transport|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of transmembrane transport|
|anion transport|
|regulation of ion transport|
|membrane organization|
|ion transmembrane transport|
|negative regulation of molecular function|
|transmembrane transport|
|ion transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6750
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANO9 Expression in NALM6 Cells: -1.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>