ANXA1 [The Human Chemical-Genetic Interaction Map Project]

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======= ANXA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANXA1
  * **<color #00a2e8>Official Name</color>**: annexin A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=301|301]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04083|P04083]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANXA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANXA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/151690|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down- regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T- cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:25664854, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Annexin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA/DNA annealing activity|
|prolactin secretion|
|positive regulation of neutrophil apoptotic process|
|myoblast migration involved in skeletal muscle regeneration|
|negative regulation of phospholipase A2 activity|
|negative regulation of T-helper 2 cell differentiation|
|phospholipase A2 inhibitor activity|
|neutrophil clearance|
|positive regulation of T-helper 1 cell differentiation|
|positive regulation of prostaglandin biosynthetic process|
|regulation of neutrophil apoptotic process|
|negative regulation of interleukin-8 secretion|
|positive regulation of myeloid cell apoptotic process|
|extrinsic component of endosome membrane|
|extrinsic component of external side of plasma membrane|
|negative regulation of phospholipase activity|
|positive regulation of unsaturated fatty acid biosynthetic process|
|regulation of prostaglandin biosynthetic process|
|regulation of T-helper 1 cell differentiation|
|positive regulation of vesicle fusion|
|regulation of T-helper 2 cell differentiation|
|regulation of unsaturated fatty acid biosynthetic process|
|neutrophil homeostasis|
|regulation of phospholipase A2 activity|
|myoblast migration|
|hepatocyte differentiation|
|negative regulation of type 2 immune response|
|negative regulation of T-helper cell differentiation|
|negative regulation of lipase activity|
|estrous cycle|
|negative regulation of interleukin-8 production|
|positive regulation of fatty acid biosynthetic process|
|cadherin binding involved in cell-cell adhesion|
|positive regulation of T-helper 1 type immune response|
|negative regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of cell migration involved in sprouting angiogenesis|
|positive regulation of T-helper cell differentiation|
|mast cell granule|
|muscle cell migration|
|arachidonate transport|
|arachidonic acid secretion|
|negative regulation of alpha-beta T cell differentiation|
|regulation of interleukin-8 secretion|
|synaptic membrane|
|icosanoid secretion|
|phagocytic cup|
|regulation of T-helper 1 type immune response|
|positive regulation of leukocyte apoptotic process|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|response to X-ray|
|regulation of myeloid cell apoptotic process|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|regulation of type 2 immune response|
|positive regulation of interleukin-2 production|
|icosanoid transport|
|fatty acid derivative transport|
|regulation of vesicle fusion|
|positive regulation of fatty acid metabolic process|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|negative regulation of exocytosis|
|regulation of T-helper cell differentiation|
|skeletal muscle tissue regeneration|
|positive regulation of G1/S transition of mitotic cell cycle|
|regulation of cell migration involved in sprouting angiogenesis|
|negative regulation of alpha-beta T cell activation|
|endocrine pancreas development|
|insulin secretion|
|positive regulation of sprouting angiogenesis|
|cellular response to vascular endothelial growth factor stimulus|
|prostate gland development|
|negative regulation of T cell differentiation|
|monocyte chemotaxis|
|regulation of fatty acid biosynthetic process|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of alpha-beta T cell differentiation|
|positive regulation of cell cycle G1/S phase transition|
|single-stranded RNA binding|
|mononuclear cell migration|
|alpha-beta T cell differentiation|
|negative regulation of lymphocyte differentiation|
|regulation of interleukin-2 production|
|positive regulation of wound healing|
|positive regulation of blood vessel endothelial cell migration|
|cellular response to glucocorticoid stimulus|
|calcium-dependent phospholipid binding|
|lateral plasma membrane|
|peptide hormone secretion|
|long-chain fatty acid transport|
|cellular response to corticosteroid stimulus|
|positive regulation of alpha-beta T cell activation|
|regulation of CD4-positive, alpha-beta T cell activation|
|peptide cross-linking|
|alpha-beta T cell activation|
|calcium-dependent protein binding|
|regulation of alpha-beta T cell differentiation|
|tissue regeneration|
|positive regulation of response to wounding|
|extrinsic component of membrane|
|cornified envelope|
|actin cytoskeleton reorganization|
|ovulation cycle|
|negative regulation of cytokine secretion|
|leukocyte homeostasis|
|regulation of sprouting angiogenesis|
|regulation of interleukin-8 production|
|cellular response to hydrogen peroxide|
|regulation of phospholipase activity|
|pancreas development|
|hormone secretion|
|fatty acid transport|
|positive regulation of mitotic cell cycle phase transition|
|protein binding, bridging|
|positive regulation of lipid biosynthetic process|
|acid secretion|
|actin filament|
|hormone transport|
|regulation of leukocyte apoptotic process|
|positive regulation of T cell differentiation|
|regulation of fatty acid metabolic process|
|granulocyte chemotaxis|
|regulation of blood vessel endothelial cell migration|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|positive regulation of cell cycle phase transition|
|positive regulation of T cell proliferation|
|regulation of interleukin-1 production|
|regulation of lipase activity|
|positive regulation of endothelial cell migration|
|sarcolemma|
|granulocyte migration|
|negative regulation of leukocyte differentiation|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|tissue remodeling|
|motile cilium|
|mitochondrial membrane|
|positive regulation of adaptive immune response|
|cell-cell adherens junction|
|phospholipid binding|
|myeloid cell homeostasis|
|single-stranded DNA binding|
|DNA duplex unwinding|
|negative regulation of T cell activation|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|DNA geometric change|
|negative regulation of immune effector process|
|endocrine system development|
|negative regulation of leukocyte cell-cell adhesion|
|liver development|
|myeloid leukocyte migration|
|hepaticobiliary system development|
|positive regulation of lymphocyte proliferation|
|cellular response to reactive oxygen species|
|positive regulation of mononuclear cell proliferation|
|negative regulation of protein secretion|
|T cell differentiation|
|response to estradiol|
|monocarboxylic acid transport|
|negative regulation of hemopoiesis|
|positive regulation of leukocyte proliferation|
|positive regulation of small molecule metabolic process|
|regulation of wound healing|
|regulation of T cell differentiation|
|negative regulation of peptide secretion|
|positive regulation of epithelial cell migration|
|positive regulation of lipid metabolic process|
|vesicle|
|cytoplasmic vesicle membrane|
|response to glucocorticoid|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|leukocyte chemotaxis|
|negative regulation of lymphocyte activation|
|positive regulation of leukocyte differentiation|
|negative regulation of immune response|
|response to ionizing radiation|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|regulation of cell shape|
|early endosome membrane|
|regeneration|
|regulation of T cell proliferation|
|regulation of endothelial cell migration|
|protein secretion|
|establishment of protein localization to extracellular region|
|regulation of adaptive immune response|
|response to corticosteroid|
|positive regulation of angiogenesis|
|regulation of cell cycle G1/S phase transition|
|protein localization to extracellular region|
|regulation of response to wounding|
|regulation of lymphocyte differentiation|
|signal release|
|regulation of cellular ketone metabolic process|
|peptide secretion|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|negative regulation of protein transport|
|positive regulation of vasculature development|
|negative regulation of establishment of protein localization|
|regulation of lipid biosynthetic process|
|positive regulation of hemopoiesis|
|cellular response to steroid hormone stimulus|
|structural molecule activity|
|response to reactive oxygen species|
|regulation of leukocyte migration|
|negative regulation of cell activation|
|basolateral plasma membrane|
|response to interleukin-1|
|homeostasis of number of cells|
|positive regulation of T cell activation|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|cell chemotaxis|
|cellular response to toxic substance|
|gliogenesis|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of epithelial cell migration|
|regulation of leukocyte proliferation|
|regulation of exocytosis|
|negative regulation of secretion|
|T cell activation|
|lymphocyte differentiation|
|cellular response to oxidative stress|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|positive regulation of cell-cell adhesion|
|regulation of hormone secretion|
|endosome|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|keratinocyte differentiation|
|rhythmic process|
|positive regulation of cell cycle process|
|regulation of angiogenesis|
|organic acid transport|
|carboxylic acid transport|
|regulation of leukocyte cell-cell adhesion|
|DNA conformation change|
|lipid transport|
|response to antibiotic|
|epidermal cell differentiation|
|regulation of T cell activation|
|apical plasma membrane|
|urogenital system development|
|lipid localization|
|regulation of vasculature development|
|response to steroid hormone|
|phagocytosis|
|leukocyte differentiation|
|signaling receptor binding|
|regulation of inflammatory response|
|positive regulation of lymphocyte activation|
|collagen-containing extracellular matrix|
|positive regulation of cell cycle|
|leukocyte migration|
|lymphocyte activation|
|skin development|
|response to oxidative stress|
|developmental growth|
|response to peptide hormone|
|growth|
|regulation of lipid metabolic process|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|cellular response to drug|
|positive regulation of leukocyte activation|
|gland development|
|regulation of mitotic cell cycle phase transition|
|epidermis development|
|focal adhesion|
|positive regulation of cell activation|
|reproductive structure development|
|regulation of small molecule metabolic process|
|reproductive system development|
|response to radiation|
|negative regulation of immune system process|
|regulation of cell cycle phase transition|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|negative regulation of hydrolase activity|
|organic anion transport|
|regulation of protein secretion|
|regulation of immune effector process|
|response to peptide|
|wound healing|
|negative regulation of transport|
|regulation of cell morphogenesis|
|regulation of peptide secretion|
|actin cytoskeleton organization|
|inflammatory response|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|cell-cell adhesion|
|response to toxic substance|
|regulation of lymphocyte activation|
|cellular response to lipid|
|positive regulation of cell motility|
|response to growth factor|
|regulation of hormone levels|
|response to inorganic substance|
|positive regulation of cellular component movement|
|cellular response to organic cyclic compound|
|chemotaxis|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|taxis|
|hemopoiesis|
|actin filament-based process|
|response to wounding|
|anion transport|
|protein-containing complex|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|cell surface|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|regulation of cell activation|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|epithelial cell differentiation|
|regulation of cell adhesion|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of protein transport|
|negative regulation of cell differentiation|
|calcium ion binding|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of cell cycle process|
|regulation of defense response|
|innate immune response|
|negative regulation of catalytic activity|
|regulation of secretion|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|defense response to other organism|
|cell migration|
|positive regulation of cell differentiation|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of cellular component movement|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|response to drug|
|regulation of protein localization|
|export from cell|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to cytokine|
|cytoskeleton organization|
|epithelium development|
|cell-cell signaling|
|secretion|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|ion transport|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|peptide transport|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|extracellular space|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12863
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANXA1 Expression in NALM6 Cells: -1.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>