APBA2 [The Human Chemical-Genetic Interaction Map Project]

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======= APBA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APBA2
  * **<color #00a2e8>Official Name</color>**: amyloid beta precursor protein binding family A member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=321|321]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99767|Q99767]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APBA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APBA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602712|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PID|
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of synaptic vesicle exocytosis|
|amyloid-beta binding|
|multicellular organism growth|
|Schaffer collateral - CA1 synapse|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|synaptic vesicle|
|regulation of neurotransmitter transport|
|dendritic spine|
|regulation of regulated secretory pathway|
|locomotory behavior|
|regulation of exocytosis|
|synapse|
|regulation of neurotransmitter levels|
|in utero embryonic development|
|developmental growth|
|growth|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|regulation of vesicle-mediated transport|
|behavior|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of cellular localization|
|embryo development|
|identical protein binding|
|cell-cell signaling|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-2.11|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.8|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.94|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.15|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8322
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.41 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APBA2 Expression in NALM6 Cells: 1.41'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>