APBB1 [The Human Chemical-Genetic Interaction Map Project]

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======= APBB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APBB1
  * **<color #00a2e8>Official Name</color>**: amyloid beta precursor protein binding family B member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=322|322]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00213|O00213]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APBB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APBB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602709|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WW|
|PID|
|PTB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of thymidylate synthase biosynthetic process|
|regulation of thymidylate synthase biosynthetic process|
|growth cone lamellipodium|
|growth cone filopodium|
|main axon|
|proline-rich region binding|
|response to iron ion|
|tau protein binding|
|histone H4 acetylation|
|positive regulation of DNA repair|
|presynaptic membrane|
|amyloid-beta binding|
|positive regulation of response to DNA damage stimulus|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|regulation of DNA repair|
|growth cone|
|histone binding|
|protein acetylation|
|cell cycle arrest|
|dendritic spine|
|lamellipodium|
|double-strand break repair|
|negative regulation of cell growth|
|protein acylation|
|positive regulation of DNA metabolic process|
|postsynaptic membrane|
|regulation of response to DNA damage stimulus|
|negative regulation of growth|
|protein-containing complex binding|
|synapse|
|positive regulation of protein secretion|
|positive regulation of neuron projection development|
|positive regulation of peptide secretion|
|ubiquitin protein ligase binding|
|peptidyl-lysine modification|
|transcription factor binding|
|regulation of DNA metabolic process|
|histone modification|
|positive regulation of neuron differentiation|
|response to metal ion|
|neuronal cell body|
|axonogenesis|
|covalent chromatin modification|
|positive regulation of cell projection organization|
|chromatin binding|
|nuclear speck|
|positive regulation of secretion by cell|
|axon development|
|regulation of cell growth|
|positive regulation of protein transport|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of peptide secretion|
|regulation of neuron projection development|
|DNA repair|
|cell part morphogenesis|
|response to inorganic substance|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell morphogenesis involved in differentiation|
|negative regulation of cell cycle|
|protein-containing complex|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|chromatin organization|
|regulation of protein transport|
|regulation of cell projection organization|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|DNA metabolic process|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|cellular response to DNA damage stimulus|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|positive regulation of transport|
|cell cycle process|
|neuron differentiation|
|regulation of protein localization|
|programmed cell death|
|chromosome organization|
|cell death|
|negative regulation of protein metabolic process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of cell death|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.94|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.72|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.543|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17297
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APBB1 Expression in NALM6 Cells: -1.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>