APOD [The Human Chemical-Genetic Interaction Map Project]

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======= APOD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APOD
  * **<color #00a2e8>Official Name</color>**: apolipoprotein D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=347|347]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05090|P05090]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APOD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APOD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107740|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lipocalin 2|
|Lipocalin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of lipoprotein lipid oxidation|
|negative regulation of lipoprotein oxidation|
|regulation of lipoprotein lipid oxidation|
|regulation of lipoprotein oxidation|
|negative regulation of smooth muscle cell-matrix adhesion|
|regulation of smooth muscle cell-matrix adhesion|
|negative regulation of lipoprotein metabolic process|
|negative regulation of T cell migration|
|peripheral nervous system axon regeneration|
|negative regulation of monocyte chemotactic protein-1 production|
|cytosolic ribosome|
|negative regulation of protein import into nucleus|
|negative regulation of protein import|
|negative regulation of platelet-derived growth factor receptor signaling pathway|
|regulation of lipoprotein metabolic process|
|negative regulation of lymphocyte migration|
|regulation of monocyte chemotactic protein-1 production|
|negative regulation of cytokine production involved in inflammatory response|
|negative regulation of focal adhesion assembly|
|negative regulation of chemokine production|
|negative regulation of nucleocytoplasmic transport|
|negative regulation of adherens junction organization|
|regulation of platelet-derived growth factor receptor signaling pathway|
|axon regeneration|
|negative regulation of cell junction assembly|
|neuron projection regeneration|
|negative regulation of protein localization to nucleus|
|lipid transporter activity|
|negative regulation of cell-matrix adhesion|
|regulation of cytokine production involved in inflammatory response|
|negative regulation of intracellular protein transport|
|regulation of T cell migration|
|negative regulation of leukocyte migration|
|negative regulation of smooth muscle cell proliferation|
|response to axon injury|
|cholesterol binding|
|regulation of protein import into nucleus|
|regulation of protein import|
|negative regulation of intracellular transport|
|regulation of focal adhesion assembly|
|regulation of cell-substrate junction assembly|
|regulation of lymphocyte migration|
|negative regulation of cell-substrate adhesion|
|tissue regeneration|
|regulation of adherens junction organization|
|regulation of chemokine production|
|negative regulation of lipid metabolic process|
|regulation of cell junction assembly|
|regulation of nucleocytoplasmic transport|
|negative regulation of cellular protein localization|
|glucose metabolic process|
|regulation of cell-matrix adhesion|
|regulation of protein localization to nucleus|
|regulation of smooth muscle cell proliferation|
|negative regulation of inflammatory response|
|regeneration|
|hexose metabolic process|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|response to reactive oxygen species|
|regulation of leukocyte migration|
|monosaccharide metabolic process|
|negative regulation of defense response|
|regulation of cell-substrate adhesion|
|regulation of intracellular protein transport|
|negative regulation of cell migration|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|negative regulation of cytokine production|
|aging|
|lipid transport|
|negative regulation of cellular component movement|
|angiogenesis|
|lipid localization|
|negative regulation of locomotion|
|regulation of inflammatory response|
|regulation of intracellular transport|
|negative regulation of response to external stimulus|
|neuronal cell body|
|response to oxidative stress|
|developmental growth|
|growth|
|regulation of lipid metabolic process|
|blood vessel morphogenesis|
|axon development|
|dendrite|
|negative regulation of immune system process|
|carbohydrate metabolic process|
|wound healing|
|negative regulation of transport|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|regulation of cellular protein localization|
|response to wounding|
|tube morphogenesis|
|neuron projection development|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of defense response|
|head development|
|neuron development|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|endoplasmic reticulum|
|neuron differentiation|
|response to drug|
|regulation of protein localization|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|generation of neurons|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|regulation of immune system process|
|cellular response to stress|
|small molecule metabolic process|
|tissue development|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15954
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APOD Expression in NALM6 Cells: -1.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>