AQP7 [The Human Chemical-Genetic Interaction Map Project]

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======= AQP7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AQP7
  * **<color #00a2e8>Official Name</color>**: aquaporin 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=364|364]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14520|O14520]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AQP7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AQP7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602974|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the aquaporin family of water-selective membrane channels. The encoded protein localizes to the plasma membrane and allows movement of water, glycerol and urea across cell membranes. This gene is highly expressed in the adipose tissue where the encoded protein facilitates efflux of glycerol. In the proximal straight tubules of kidney, the encoded protein is localized to the apical membrane and prevents excretion of glycerol into urine. The encoded protein is present in spermatids, as well as in the testicular and epididymal spermatozoa suggesting an important role in late spermatogenesis. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. This gene is located adjacent to a related aquaporin gene on chromosome 9. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Forms a channel for water and glycerol.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MIP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycerol channel activity|
|glycerol transport|
|urea transmembrane transporter activity|
|urea transmembrane transport|
|urea transport|
|water channel activity|
|polyol transport|
|one-carbon compound transport|
|water transport|
|fluid transport|
|carbohydrate transport|
|lipid droplet|
|cell cortex|
|organic hydroxy compound transport|
|cytoplasmic vesicle membrane|
|cell-cell junction|
|transmembrane transport|
|integral component of plasma membrane|
|amide transport|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 221/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|14/28|
|blood|6/28|
|bone|12/26|
|breast|7/33|
|central nervous system|18/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|10/21|
|liver|8/20|
|lung|21/75|
|lymphocyte|6/16|
|ovary|10/26|
|pancreas|4/24|
|peripheral nervous system|7/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|7/22|
|urinary tract|7/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3625
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AQP7 Expression in NALM6 Cells: -0.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>