ARHGEF2 [The Human Chemical-Genetic Interaction Map Project]

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======= ARHGEF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARHGEF2
  * **<color #00a2e8>Official Name</color>**: Rho/Rac guanine nucleotide exchange factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9181|9181]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92974|Q92974]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARHGEF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARHGEF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607560|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF- alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RhoGEF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of podosome assembly|
|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|
|asymmetric neuroblast division|
|regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|
|cellular response to muramyl dipeptide|
|regulation of cellular response to osmotic stress|
|asymmetric stem cell division|
|cellular hyperosmotic response|
|negative regulation of necroptotic process|
|negative regulation of programmed necrotic cell death|
|regulation of response to osmotic stress|
|neuroblast division|
|neuronal stem cell division|
|asymmetric cell division|
|regulation of podosome assembly|
|negative regulation of necrotic cell death|
|positive regulation of neuron migration|
|regulation of necroptotic process|
|Rac guanyl-nucleotide exchange factor activity|
|postsynaptic density, intracellular component|
|regulation of programmed necrotic cell death|
|response to muramyl dipeptide|
|somatic stem cell division|
|hyperosmotic response|
|negative regulation of microtubule depolymerization|
|establishment of mitotic spindle orientation|
|regulation of necrotic cell death|
|regulation of microtubule depolymerization|
|podosome|
|Rho GTPase binding|
|neuroblast proliferation|
|establishment of mitotic spindle localization|
|stem cell division|
|cellular response to osmotic stress|
|establishment of spindle orientation|
|dendritic shaft|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of microtubule polymerization or depolymerization|
|negative regulation of organelle assembly|
|regulation of neuron migration|
|establishment of spindle localization|
|spindle localization|
|stem cell proliferation|
|Rac GTPase binding|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of protein depolymerization|
|Rho guanyl-nucleotide exchange factor activity|
|negative regulation of protein complex disassembly|
|neural precursor cell proliferation|
|response to osmotic stress|
|regulation of microtubule polymerization or depolymerization|
|regulation of protein depolymerization|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of interleukin-6 production|
|ruffle membrane|
|negative regulation of intrinsic apoptotic signaling pathway|
|negative regulation of extrinsic apoptotic signaling pathway|
|microtubule cytoskeleton organization involved in mitosis|
|regulation of protein complex disassembly|
|establishment of cell polarity|
|spindle|
|bicellular tight junction|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein complex assembly|
|negative regulation of cytoskeleton organization|
|regulation of interleukin-6 production|
|vesicle|
|regulation of Rho protein signal transduction|
|regulation of tumor necrosis factor production|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of extrinsic apoptotic signaling pathway|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of microtubule cytoskeleton organization|
|positive regulation of peptidyl-tyrosine phosphorylation|
|establishment or maintenance of cell polarity|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|negative regulation of apoptotic signaling pathway|
|microtubule binding|
|actin filament organization|
|cellular response to tumor necrosis factor|
|regulation of Ras protein signal transduction|
|cell fate commitment|
|regulation of peptidyl-tyrosine phosphorylation|
|cytoplasmic vesicle|
|positive regulation of DNA-binding transcription factor activity|
|response to tumor necrosis factor|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|microtubule|
|cellular response to peptide|
|transcription factor binding|
|negative regulation of cell development|
|regulation of small GTPase mediated signal transduction|
|glutamatergic synapse|
|regulation of supramolecular fiber organization|
|establishment of organelle localization|
|cytoskeleton|
|positive regulation of neuron differentiation|
|neuronal cell body|
|negative regulation of organelle organization|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|focal adhesion|
|regulation of DNA-binding transcription factor activity|
|positive regulation of cytokine production|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|positive regulation of neurogenesis|
|response to peptide|
|microtubule cytoskeleton organization|
|cell division|
|actin cytoskeleton organization|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|positive regulation of cell motility|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|positive regulation of locomotion|
|cell population proliferation|
|actin filament-based process|
|organelle localization|
|protein-containing complex|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|microtubule-based process|
|mitotic cell cycle|
|regulation of cytokine production|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|regulation of cellular response to stress|
|innate immune response|
|regulation of neurogenesis|
|cellular component morphogenesis|
|zinc ion binding|
|regulation of cell migration|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|defense response to other organism|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|intracellular protein transport|
|negative regulation of cell death|
|cell cycle process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|response to drug|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|response to cytokine|
|cytoskeleton organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.99|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.83|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5151
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARHGEF2 Expression in NALM6 Cells: 7.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>