ARL13A [The Human Chemical-Genetic Interaction Map Project]

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======= ARL13A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARL13A
  * **<color #00a2e8>Official Name</color>**: ADP ribosylation factor like GTPase 13A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=392509|392509]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5H913|Q5H913]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARL13A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARL13A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/301144|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SRPRB|
|Miro|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|receptor localization to non-motile cilium|
|protein localization to ciliary membrane|
|protein localization to non-motile cilium|
|non-motile cilium|
|non-motile cilium assembly|
|protein localization to cilium|
|ciliary membrane|
|cilium|
|protein localization to cell periphery|
|cilium assembly|
|cilium organization|
|GTP binding|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|protein localization to membrane|
|protein localization to organelle|
|organelle assembly|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular protein localization|
|cellular macromolecule localization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.01|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18227
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARL13A Expression in NALM6 Cells: -0.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>