ARL14EP [The Human Chemical-Genetic Interaction Map Project]

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======= ARL14EP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARL14EP
  * **<color #00a2e8>Official Name</color>**: ADP ribosylation factor like GTPase 14 effector protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=120534|120534]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N8R7|Q8N8R7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARL14EP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARL14EP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612295|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an effector protein. It interacts with ADP-ribosylation factor-like 14 [ARL14, also known as ADP-ribosylation factor 7 (ARF7)], beta-actin (ACTB) and actin-based motor protein myosin 1E (MYO1E). ARL14 is a small GTPase; it controls the export of major histocompatibility class II molecules by connecting to the actin network via this effector protein. [provided by RefSeq, Sep 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. {ECO:0000269|PubMed:21458045}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|focal adhesion|
|intracellular membrane-bounded organelle|
|nucleolus|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.7|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-2.01|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-2.01|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.91|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.77|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.81|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.83|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.07|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cbx3|CBX3]]|0.552|
|[[:human genes:t:trim28|TRIM28]]|0.521|
|[[:human genes:f:fbxo11|FBXO11]]|0.471|
|[[:human genes:z:znf445|ZNF445]]|0.445|
|[[:human genes:s:setdb1|SETDB1]]|0.439|
|[[:human genes:i:id3|ID3]]|0.439|
|[[:human genes:t:trip12|TRIP12]]|0.435|
|[[:human genes:a:asb7|ASB7]]|0.43|
|[[:human genes:a:ambra1|AMBRA1]]|0.425|
|[[:human genes:a:atf7ip|ATF7IP]]|0.424|
|[[:human genes:b:bap1|BAP1]]|0.419|
|[[:human genes:u:ubr5|UBR5]]|0.407|
|[[:human genes:d:dohh|DOHH]]|0.406|
|[[:human genes:m:mllt1|MLLT1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17435
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARL14EP Expression in NALM6 Cells: 5.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>