ARL6IP1 [The Human Chemical-Genetic Interaction Map Project]

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======= ARL6IP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARL6IP1
  * **<color #00a2e8>Official Name</color>**: ADP ribosylation factor like GTPase 6 interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23204|23204]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15041|Q15041]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARL6IP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARL6IP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607669|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the ARL6ip family and encodes a transmembrane protein that is predominantly localized to intracytoplasmic membranes. It is highly expressed in early myeloid progenitor cells and thought to be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Mutations in this gene are associated with spastic paraplegia 61 (SPG61). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity). Plays a role in the formation and stabilization of endoplasmic reticulum tubules (PubMed:24262037). Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself (PubMed:12754298). May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (PubMed:10995579). {ECO:0000250|UniProtKB:Q9JKW0, ECO:0000269|PubMed:12754298, ECO:0000269|PubMed:24262037, ECO:0000303|PubMed:10995579}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Reticulon|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of L-glutamate import across plasma membrane|
|endoplasmic reticulum tubular network membrane organization|
|endoplasmic reticulum tubular network formation|
|regulation of L-glutamate import across plasma membrane|
|Sec61 translocon complex|
|positive regulation of neurotransmitter uptake|
|regulation of amino acid import across plasma membrane|
|positive regulation of anion transmembrane transport|
|regulation of amino acid transmembrane transport|
|endoplasmic reticulum tubular network organization|
|positive regulation of amino acid transport|
|regulation of neurotransmitter uptake|
|regulation of anion transmembrane transport|
|positive regulation of response to drug|
|regulation of amino acid transport|
|positive regulation of organic acid transport|
|positive regulation of amine transport|
|positive regulation of neurotransmitter transport|
|positive regulation of anion transport|
|endoplasmic reticulum organization|
|regulation of organic acid transport|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cysteine-type endopeptidase activity|
|regulation of amine transport|
|regulation of anion transport|
|regulation of response to drug|
|cotranslational protein targeting to membrane|
|integral component of endoplasmic reticulum membrane|
|regulation of neurotransmitter transport|
|positive regulation of ion transmembrane transport|
|protein targeting to membrane|
|positive regulation of transmembrane transport|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|establishment of protein localization to membrane|
|positive regulation of ion transport|
|regulation of neurotransmitter levels|
|negative regulation of proteolysis|
|protein targeting|
|regulation of endopeptidase activity|
|endomembrane system organization|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|regulation of transmembrane transport|
|regulation of ion transport|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|membrane organization|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|endoplasmic reticulum membrane|
|positive regulation of transport|
|negative regulation of cell death|
|intracellular protein transport|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|identical protein binding|
|cell death|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell death|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.86|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.8|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.89|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11033
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARL6IP1 Expression in NALM6 Cells: 8.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>