ARNT [The Human Chemical-Genetic Interaction Map Project]

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======= ARNT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARNT
  * **<color #00a2e8>Official Name</color>**: aryl hydrocarbon receptor nuclear translocator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=405|405]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P27540|P27540]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARNT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARNT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/126110|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAS|
|HLH|
|PAS 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|aryl hydrocarbon receptor binding|
|positive regulation of hormone biosynthetic process|
|positive regulation of protein sumoylation|
|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|
|sequence-specific double-stranded DNA binding|
|positive regulation of hormone metabolic process|
|positive regulation of vascular endothelial growth factor receptor signaling pathway|
|enhancer binding|
|mRNA transcription by RNA polymerase II|
|regulation of protein sumoylation|
|positive regulation of glycolytic process|
|mRNA transcription|
|regulation of hormone biosynthetic process|
|positive regulation of vascular endothelial growth factor production|
|positive regulation of erythrocyte differentiation|
|regulation of vascular endothelial growth factor production|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|regulation of hormone metabolic process|
|positive regulation of ATP metabolic process|
|positive regulation of nucleotide metabolic process|
|positive regulation of purine nucleotide metabolic process|
|regulation of erythrocyte differentiation|
|nuclear receptor activity|
|RNA polymerase II transcription factor complex|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|regulation of glycolytic process|
|positive regulation of carbohydrate metabolic process|
|embryonic placenta development|
|regulation of carbohydrate catabolic process|
|positive regulation of myeloid cell differentiation|
|positive regulation of endothelial cell proliferation|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of ATP metabolic process|
|regulation of DNA-templated transcription in response to stress|
|regulation of endothelial cell proliferation|
|xenobiotic metabolic process|
|positive regulation of protein modification by small protein conjugation or removal|
|positive regulation of small molecule metabolic process|
|placenta development|
|regulation of generation of precursor metabolites and energy|
|intracellular receptor signaling pathway|
|cellular response to xenobiotic stimulus|
|positive regulation of hemopoiesis|
|cellular response to hypoxia|
|positive regulation of epithelial cell proliferation|
|cellular response to decreased oxygen levels|
|regulation of carbohydrate metabolic process|
|cellular response to oxygen levels|
|regulation of myeloid cell differentiation|
|regulation of protein modification by small protein conjugation or removal|
|cellular response to oxidative stress|
|regulation of cellular response to growth factor stimulus|
|nuclear body|
|transcription coactivator activity|
|response to xenobiotic stimulus|
|transcription factor binding|
|regulation of epithelial cell proliferation|
|response to hypoxia|
|response to decreased oxygen levels|
|positive regulation of cellular catabolic process|
|in utero embryonic development|
|response to oxygen levels|
|response to oxidative stress|
|sequence-specific DNA binding|
|reproductive structure development|
|regulation of small molecule metabolic process|
|reproductive system development|
|positive regulation of catabolic process|
|embryonic organ development|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|regulation of hormone levels|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|mRNA metabolic process|
|regulation of cytokine production|
|regulation of cellular catabolic process|
|protein homodimerization activity|
|positive regulation of cell population proliferation|
|positive regulation of cell differentiation|
|embryo development|
|regulation of catabolic process|
|positive regulation of phosphorylation|
|nucleobase-containing compound biosynthetic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|organic cyclic compound biosynthetic process|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|RNA metabolic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.73|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|6.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hif1a|HIF1A]]|0.524|
|[[:human genes:s:slc16a7|SLC16A7]]|0.42|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5217
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARNT Expression in NALM6 Cells: 5.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>