ARSB [The Human Chemical-Genetic Interaction Map Project]

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======= ARSB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARSB
  * **<color #00a2e8>Official Name</color>**: arylsulfatase B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=411|411]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15848|P15848]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARSB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARSB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611542|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). {ECO:0000250|UniProtKB:P50430, ECO:0000269|PubMed:19306108}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sulfatase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|colon epithelial cell migration|
|N-acetylgalactosamine-4-sulfatase activity|
|intestinal epithelial cell migration|
|response to methylmercury|
|chondroitin sulfate catabolic process|
|arylsulfatase activity|
|chondroitin sulfate metabolic process|
|response to pH|
|chondroitin sulfate proteoglycan metabolic process|
|sulfur compound catabolic process|
|lysosome organization|
|lytic vacuole organization|
|rough endoplasmic reticulum|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|response to estrogen|
|epithelial cell migration|
|epithelium migration|
|azurophil granule lumen|
|proteoglycan metabolic process|
|tissue migration|
|lysosomal lumen|
|lysosomal transport|
|mucopolysaccharide metabolic process|
|ficolin-1-rich granule lumen|
|vacuole organization|
|vacuolar transport|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|ameboidal-type cell migration|
|carbohydrate derivative catabolic process|
|response to nutrient|
|regulation of epithelial cell migration|
|lysosome|
|autophagy|
|process utilizing autophagic mechanism|
|positive regulation of neuron projection development|
|endoplasmic reticulum lumen|
|sulfur compound metabolic process|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|glycoprotein metabolic process|
|positive regulation of neurogenesis|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of neuron projection development|
|response to nutrient levels|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|response to extracellular stimulus|
|positive regulation of nervous system development|
|positive regulation of cell development|
|myeloid leukocyte activation|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulated exocytosis|
|regulation of cell projection organization|
|leukocyte mediated immunity|
|exocytosis|
|regulation of neurogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|cell migration|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|oxoacid metabolic process|
|secretion by cell|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|export from cell|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|secretion|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|mitochondrion|
|locomotion|
|positive regulation of developmental process|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.591|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7628
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARSB Expression in NALM6 Cells: 4.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>