ASCC3 [The Human Chemical-Genetic Interaction Map Project]

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======= ASCC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ASCC3
  * **<color #00a2e8>Official Name</color>**: activating signal cointegrator 1 complex subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10973|10973]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N3C0|Q8N3C0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ASCC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ASCC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614217|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation. {ECO:0000269|PubMed:22055184}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Helicase C|
|ResIII|
|DEAD|
|Sec63|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activating signal cointegrator 1 complex|
|DNA dealkylation involved in DNA repair|
|3-5 DNA helicase activity|
|DNA dealkylation|
|helicase activity|
|intracellular|
|DNA modification|
|DNA duplex unwinding|
|DNA geometric change|
|DNA conformation change|
|nuclear speck|
|DNA repair|
|cell population proliferation|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|chromosome organization|
|RNA binding|
|ATP binding|
|cellular response to stress|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.08|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.84|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.8|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.74|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.73|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.73|
|[[:results:exp149|SB203580 25μM R03 exp149]]|1.73|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.91|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|3.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2062
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ASCC3 Expression in NALM6 Cells: 7.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>