ASH1L [The Human Chemical-Genetic Interaction Map Project]

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======= ASH1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ASH1L
  * **<color #00a2e8>Official Name</color>**: ASH1 like histone lysine methyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55870|55870]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NR48|Q9NR48]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ASH1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ASH1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607999|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Histone methyltransferase specifically methylating 'Lys- 36' of histone H3 (H3K36me). {ECO:0000269|PubMed:21239497}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Bromodomain|
|PHD|
|BAH|
|SET|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|uterine gland development|
|tarsal gland development|
|histone H3-K36 dimethylation|
|uterus morphogenesis|
|histone methyltransferase activity (H3-K36 specific)|
|sebaceous gland development|
|histone H3-K36 methylation|
|histone methyltransferase activity (H3-K9 specific)|
|interleukin-6 production|
|negative regulation of acute inflammatory response|
|peptidyl-lysine dimethylation|
|histone H3-K9 methylation|
|histone methyltransferase activity (H3-K4 specific)|
|histone H3-K9 modification|
|uterus development|
|decidualization|
|maternal placenta development|
|histone H3-K4 methylation|
|negative regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of acute inflammatory response|
|maternal process involved in female pregnancy|
|sperm motility|
|flagellated sperm motility|
|histone lysine methylation|
|peptidyl-lysine methylation|
|post-embryonic development|
|histone methylation|
|cilium or flagellum-dependent cell motility|
|cilium-dependent cell motility|
|chromosome|
|bicellular tight junction|
|protein methylation|
|protein alkylation|
|negative regulation of inflammatory response|
|single fertilization|
|cytokine production|
|placenta development|
|negative regulation of MAPK cascade|
|fertilization|
|DNA packaging|
|female pregnancy|
|negative regulation of defense response|
|multi-multicellular organism process|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|macromolecule methylation|
|DNA conformation change|
|methylation|
|peptidyl-lysine modification|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|histone modification|
|covalent chromatin modification|
|skin development|
|chromatin binding|
|negative regulation of protein phosphorylation|
|gland development|
|reproductive structure development|
|reproductive system development|
|negative regulation of phosphorylation|
|transcription by RNA polymerase II|
|skeletal system development|
|negative regulation of intracellular signal transduction|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|developmental process involved in reproduction|
|chromatin organization|
|regulation of MAPK cascade|
|regulation of defense response|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|peptidyl-amino acid modification|
|animal organ morphogenesis|
|Golgi apparatus|
|multi-organism reproductive process|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|organic cyclic compound biosynthetic process|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|DNA binding|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.24|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.76|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.93|
|[[:results:exp149|SB203580 25μM R03 exp149]]|2.18|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10847
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ASH1L Expression in NALM6 Cells: 6.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>