ASIP [The Human Chemical-Genetic Interaction Map Project]

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======= ASIP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ASIP
  * **<color #00a2e8>Official Name</color>**: agouti signaling protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=434|434]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42127|P42127]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ASIP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ASIP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600201|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Agouti|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of molecular function, epigenetic|
|type 4 melanocortin receptor binding|
|type 3 melanocortin receptor binding|
|positive regulation of melanin biosynthetic process|
|positive regulation of secondary metabolite biosynthetic process|
|regulation of melanin biosynthetic process|
|adult feeding behavior|
|regulation of secondary metabolite biosynthetic process|
|regulation of secondary metabolic process|
|melanin biosynthetic process|
|melanin metabolic process|
|secondary metabolite biosynthetic process|
|melanosome transport|
|establishment of melanosome localization|
|pigment granule transport|
|establishment of pigment granule localization|
|genetic imprinting|
|melanosome localization|
|melanosome organization|
|pigment granule organization|
|pigment granule localization|
|phenol-containing compound biosynthetic process|
|cellular pigmentation|
|pigment biosynthetic process|
|secondary metabolic process|
|pigment metabolic process|
|cell|
|phenol-containing compound metabolic process|
|feeding behavior|
|pigmentation|
|adult behavior|
|hormone-mediated signaling pathway|
|establishment of vesicle localization|
|vesicle localization|
|organic hydroxy compound biosynthetic process|
|vesicle organization|
|signaling receptor binding|
|establishment of organelle localization|
|generation of precursor metabolites and energy|
|organic hydroxy compound metabolic process|
|behavior|
|organelle localization|
|cellular response to hormone stimulus|
|response to hormone|
|cell-cell signaling|
|aromatic compound biosynthetic process|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|response to endogenous stimulus|
|extracellular space|
|establishment of localization in cell|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5904
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ASIP Expression in NALM6 Cells: -0.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>