ATF3 [The Human Chemical-Genetic Interaction Map Project]

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======= ATF3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATF3
  * **<color #00a2e8>Official Name</color>**: activating transcription factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=467|467]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18847|P18847]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATF3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATF3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603148|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|bZIP 1|
|bZIP 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CHOP-ATF3 complex|
|regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|
|positive regulation of TRAIL-activated apoptotic signaling pathway|
|regulation of TRAIL-activated apoptotic signaling pathway|
|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|
|PERK-mediated unfolded protein response|
|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|cellular response to arsenic-containing substance|
|positive regulation of transcription from RNA polymerase II promoter in response to stress|
|response to arsenic-containing substance|
|ER-nucleus signaling pathway|
|cellular response to amino acid starvation|
|gluconeogenesis|
|response to amino acid starvation|
|hexose biosynthetic process|
|positive regulation of extrinsic apoptotic signaling pathway|
|skeletal muscle cell differentiation|
|monosaccharide biosynthetic process|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of ERK1 and ERK2 cascade|
|transcription regulatory region sequence-specific DNA binding|
|endoplasmic reticulum unfolded protein response|
|glucose metabolic process|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|skeletal muscle tissue development|
|regulation of DNA-templated transcription in response to stress|
|cellular response to unfolded protein|
|carbohydrate biosynthetic process|
|skeletal muscle organ development|
|cellular response to topologically incorrect protein|
|cellular response to starvation|
|regulation of extrinsic apoptotic signaling pathway|
|hexose metabolic process|
|response to unfolded protein|
|negative regulation of MAPK cascade|
|positive regulation of apoptotic signaling pathway|
|response to topologically incorrect protein|
|response to starvation|
|monosaccharide metabolic process|
|transcription regulatory region DNA binding|
|cellular response to nutrient levels|
|transcription corepressor activity|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|response to endoplasmic reticulum stress|
|cellular response to extracellular stimulus|
|striated muscle tissue development|
|regulation of ERK1 and ERK2 cascade|
|muscle organ development|
|muscle tissue development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|cellular response to external stimulus|
|regulation of apoptotic signaling pathway|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|carbohydrate metabolic process|
|muscle structure development|
|protein heterodimerization activity|
|response to nutrient levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|negative regulation of intracellular signal transduction|
|response to extracellular stimulus|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|small molecule biosynthetic process|
|negative regulation of protein modification process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|DNA-binding transcription factor activity|
|positive regulation of cell death|
|regulation of MAPK cascade|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|protein homodimerization activity|
|positive regulation of cell population proliferation|
|negative regulation of cellular protein metabolic process|
|identical protein binding|
|negative regulation of protein metabolic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18462
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATF3 Expression in NALM6 Cells: 2.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>