ATG14 [The Human Chemical-Genetic Interaction Map Project]

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======= ATG14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATG14
  * **<color #00a2e8>Official Name</color>**: autophagy related 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22863|22863]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZNE5|Q6ZNE5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATG14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATG14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613515|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t- SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q8CDJ3, ECO:0000269|PubMed:18843052, ECO:0000269|PubMed:19050071, ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:20713597, ECO:0000269|PubMed:23878393, ECO:0000269|PubMed:25686604}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Atg14|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extrinsic component of phagophore assembly site membrane|
|extrinsic component of omegasome membrane|
|autophagosome membrane docking|
|phosphatidylinositol 3-kinase complex, class III|
|mitophagy|
|regulation of protein complex stability|
|mitochondria-associated endoplasmic reticulum membrane|
|phagophore assembly site membrane|
|response to mitochondrial depolarisation|
|selective autophagy|
|positive regulation of phosphatidylinositol 3-kinase activity|
|autophagosome maturation|
|autophagosome membrane|
|GTPase binding|
|regulation of triglyceride metabolic process|
|positive regulation of lipid kinase activity|
|autophagy of mitochondrion|
|mitochondrion disassembly|
|cellular response to glucose starvation|
|positive regulation of phospholipid metabolic process|
|endosome to lysosome transport|
|regulation of phosphatidylinositol 3-kinase activity|
|phagocytic vesicle|
|autophagosome assembly|
|regulation of lipid kinase activity|
|organelle disassembly|
|autophagosome organization|
|autophagosome|
|regulation of phospholipid metabolic process|
|axoneme|
|lysosomal transport|
|vacuole organization|
|positive regulation of lipid metabolic process|
|vacuolar transport|
|cellular response to starvation|
|macroautophagy|
|organelle localization by membrane tethering|
|membrane docking|
|response to starvation|
|cellular response to nutrient levels|
|protein-containing complex disassembly|
|process utilizing autophagic mechanism|
|autophagy|
|cellular response to extracellular stimulus|
|cellular response to external stimulus|
|regulation of lipid metabolic process|
|cellular component disassembly|
|negative regulation of protein phosphorylation|
|mitochondrion organization|
|negative regulation of phosphorylation|
|response to nutrient levels|
|posttranscriptional regulation of gene expression|
|response to extracellular stimulus|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|positive regulation of kinase activity|
|organelle localization|
|negative regulation of protein modification process|
|positive regulation of transferase activity|
|organelle assembly|
|regulation of kinase activity|
|endoplasmic reticulum membrane|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|negative regulation of protein metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|intracellular transport|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.79|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7633
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATG14 Expression in NALM6 Cells: 5.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>