ATG9A [The Human Chemical-Genetic Interaction Map Project]

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======= ATG9A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATG9A
  * **<color #00a2e8>Official Name</color>**: autophagy related 9A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79065|79065]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z3C6|Q7Z3C6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATG9A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATG9A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612204|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|APG9|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|late nucleophagy|
|autophagy of nucleus|
|protein localization to phagophore assembly site|
|phagophore assembly site|
|autophagosome membrane|
|mitochondrion disassembly|
|autophagy of mitochondrion|
|autophagosome assembly|
|organelle disassembly|
|autophagosome organization|
|autophagosome|
|recycling endosome|
|late endosome membrane|
|synaptic vesicle|
|late endosome|
|vacuole organization|
|macroautophagy|
|trans-Golgi network|
|autophagy|
|process utilizing autophagic mechanism|
|endosome|
|cellular component disassembly|
|mitochondrion organization|
|response to nutrient levels|
|response to extracellular stimulus|
|intracellular membrane-bounded organelle|
|organelle assembly|
|endoplasmic reticulum membrane|
|protein transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular catabolic process|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-3.6|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-3.25|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-3.08|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.47|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.41|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.33|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.26|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-2.17|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.09|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-2.09|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.01|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.97|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-1.86|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.85|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.83|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.81|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.78|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.71|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.7|
|[[:results:exp453|B02 10μM R08 exp453]]|1.79|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.79|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.93|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.95|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.95|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.98|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|2|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c12orf44|C12orf44]]|0.543|
|[[:human genes:s:sec62|SEC62]]|0.453|
|[[:human genes:w:wipi2|WIPI2]]|0.448|
|[[:human genes:d:dpm1|DPM1]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14429
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATG9A Expression in NALM6 Cells: 5.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>