ATL2 [The Human Chemical-Genetic Interaction Map Project]

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======= ATL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATL2
  * **<color #00a2e8>Official Name</color>**: atlastin GTPase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64225|64225]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NHH9|Q8NHH9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609368|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:18270207, PubMed:19665976, PubMed:27619977). {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:27619977}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GBP|
|GBP C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endoplasmic reticulum tubular network membrane organization|
|endoplasmic reticulum tubular network membrane|
|endoplasmic reticulum tubular network organization|
|endoplasmic reticulum organization|
|Golgi organization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|GTPase activity|
|protein homooligomerization|
|Golgi vesicle transport|
|GTP binding|
|endomembrane system organization|
|protein complex oligomerization|
|membrane organization|
|endoplasmic reticulum membrane|
|endoplasmic reticulum|
|identical protein binding|
|intracellular transport|
|protein-containing complex assembly|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.48|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.34|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.29|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.76|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.7|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.92|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.93|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.98|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.559|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 213/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|9/28|
|bone|7/26|
|breast|7/33|
|central nervous system|18/56|
|cervix|0/4|
|colorectal|5/17|
|esophagus|2/13|
|fibroblast|1/1|
|gastric|4/16|
|kidney|6/21|
|liver|9/20|
|lung|16/75|
|lymphocyte|7/16|
|ovary|8/26|
|pancreas|3/24|
|peripheral nervous system|7/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|12/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|7/22|
|urinary tract|10/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2066
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATL2 Expression in NALM6 Cells: 6.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>