ATP13A2 [The Human Chemical-Genetic Interaction Map Project]

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======= ATP13A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP13A2
  * **<color #00a2e8>Official Name</color>**: ATPase cation transporting 13A2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23400|23400]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQ11|Q9NQ11]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP13A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP13A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610513|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity (PubMed:22186024). Required for a proper lysosomal and mitochondrial maintenance (PubMed:22296644, PubMed:28137957). {ECO:0000269|PubMed:22186024, ECO:0000269|PubMed:22296644, ECO:0000269|PubMed:28137957}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hydrolase|
|P5-ATPase|
|E1-E2 ATPase|
|HAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptidyl-aspartic acid phosphorylation|
|peptidyl-aspartic acid autophosphorylation|
|polyamine transmembrane transport|
|regulation of autophagosome size|
|regulation of glucosylceramidase activity|
|ATPase-coupled cation transmembrane transporter activity|
|peptidyl-aspartic acid modification|
|integral component of lysosomal membrane|
|cupric ion binding|
|polyamine transport|
|negative regulation of lysosomal protein catabolic process|
|negative regulation of protein catabolic process in the vacuole|
|extracellular exosome biogenesis|
|extracellular vesicle biogenesis|
|regulation of chaperone-mediated autophagy|
|regulation of lysosomal protein catabolic process|
|regulation of protein catabolic process in the vacuole|
|cellular response to manganese ion|
|multivesicular body membrane|
|positive regulation of exosomal secretion|
|regulation of exosomal secretion|
|response to manganese ion|
|phosphatidic acid binding|
|cellular response to zinc ion|
|phosphatidylinositol-3,5-bisphosphate binding|
|vesicle membrane|
|multivesicular body|
|cellular zinc ion homeostasis|
|zinc ion homeostasis|
|regulation of autophagy of mitochondrion|
|response to zinc ion|
|cellular iron ion homeostasis|
|manganese ion binding|
|autophagosome organization|
|autophagosome|
|iron ion homeostasis|
|negative regulation of cellular protein catabolic process|
|positive regulation of exocytosis|
|transport vesicle|
|lysosomal lumen|
|cellular transition metal ion homeostasis|
|late endosome|
|vacuole organization|
|transition metal ion homeostasis|
|negative regulation of protein catabolic process|
|vesicle|
|macroautophagy|
|regulation of macroautophagy|
|regulation of mitochondrion organization|
|cellular response to metal ion|
|protein autophosphorylation|
|negative regulation of neuron death|
|cellular response to inorganic substance|
|regulation of exocytosis|
|regulation of intracellular protein transport|
|ATPase activity|
|cellular response to oxidative stress|
|regulation of cellular protein catabolic process|
|lysosome|
|negative regulation of cellular catabolic process|
|autophagy|
|process utilizing autophagic mechanism|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|lysosomal membrane|
|negative regulation of catabolic process|
|regulation of neuron death|
|neuron projection|
|regulation of autophagy|
|regulation of intracellular transport|
|response to metal ion|
|neuronal cell body|
|regulation of cellular component size|
|regulation of protein catabolic process|
|response to oxidative stress|
|positive regulation of secretion by cell|
|regulation of endopeptidase activity|
|positive regulation of protein transport|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|regulation of peptidase activity|
|calcium ion homeostasis|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|response to inorganic substance|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|regulation of proteolysis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|regulation of cellular catabolic process|
|zinc ion binding|
|peptidyl-amino acid modification|
|cellular homeostasis|
|regulation of cellular localization|
|ion transmembrane transport|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of catabolic process|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|transmembrane transport|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|ion transport|
|ATP binding|
|homeostatic process|
|regulation of cell death|
|cellular response to stress|
|cellular catabolic process|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15420
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP13A2 Expression in NALM6 Cells: 6.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>