ATP1A4 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= ATP1A4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP1A4
  * **<color #00a2e8>Official Name</color>**: ATPase Na+/K+ transporting subunit alpha 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=480|480]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13733|Q13733]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP1A4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP1A4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607321|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cation ATPase C|
|HAD|
|E1-E2 ATPase|
|Cation ATPase N|
|Hydrolase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sodium:potassium-exchanging ATPase activity|
|sodium:potassium-exchanging ATPase complex|
|cellular potassium ion homeostasis|
|sodium ion export across plasma membrane|
|establishment or maintenance of transmembrane electrochemical gradient|
|cellular sodium ion homeostasis|
|potassium ion homeostasis|
|sodium ion homeostasis|
|export across plasma membrane|
|potassium ion import across plasma membrane|
|regulation of cardiac conduction|
|flagellated sperm motility|
|sperm motility|
|inorganic ion import across plasma membrane|
|inorganic cation import across plasma membrane|
|sodium ion transmembrane transport|
|regulation of cellular pH|
|cilium-dependent cell motility|
|cilium or flagellum-dependent cell motility|
|import across plasma membrane|
|regulation of pH|
|cellular monovalent inorganic cation homeostasis|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|sodium ion transport|
|potassium ion transmembrane transport|
|potassium ion transport|
|fertilization|
|regulation of heart contraction|
|regulation of blood circulation|
|monovalent inorganic cation transport|
|regulation of membrane potential|
|spermatogenesis|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|male gamete generation|
|regulation of system process|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|import into cell|
|gamete generation|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|multicellular organismal reproductive process|
|cation transport|
|sexual reproduction|
|multicellular organism reproduction|
|cellular homeostasis|
|ion transmembrane transport|
|multi-organism reproductive process|
|export from cell|
|localization of cell|
|cell motility|
|chemical homeostasis|
|transmembrane transport|
|locomotion|
|ion transport|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|ATP binding|
|movement of cell or subcellular component|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9361
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP1A4 Expression in NALM6 Cells: 3.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>