ATP1B4 [The Human Chemical-Genetic Interaction Map Project]

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======= ATP1B4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP1B4
  * **<color #00a2e8>Official Name</color>**: ATPase Na+/K+ transporting family member beta 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23439|23439]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UN42|Q9UN42]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP1B4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP1B4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/301073|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit. {ECO:0000269|PubMed:17592128}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Na K-ATPase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|monovalent inorganic cation transmembrane transporter activity|
|sodium:potassium-exchanging ATPase complex|
|nuclear inner membrane|
|nuclear envelope|
|monovalent inorganic cation transport|
|cation transport|
|positive regulation of transcription by RNA polymerase II|
|ion transport|
|integral component of plasma membrane|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.53|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.3|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.9|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-1.81|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.8|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.75|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.71|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.92|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.04|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.526|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12583
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP1B4 Expression in NALM6 Cells: 2.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>