ATP2A3 [The Human Chemical-Genetic Interaction Map Project]

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======= ATP2A3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP2A3
  * **<color #00a2e8>Official Name</color>**: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=489|489]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q93084|Q93084]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP2A3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP2A3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601929|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HAD|
|Cation ATPase C|
|Cation ATPase N|
|E1-E2 ATPase|
|Hydrolase 3|
|Hydrolase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|platelet dense tubular network membrane|
|calcium transmembrane transporter activity, phosphorylative mechanism|
|proton-exporting ATPase activity, phosphorylative mechanism|
|sarcoplasmic reticulum membrane|
|sarcoplasmic reticulum|
|regulation of cardiac conduction|
|proton transmembrane transport|
|calcium ion transmembrane transport|
|nuclear membrane|
|regulation of heart contraction|
|calcium ion transport|
|regulation of blood circulation|
|divalent metal ion transport|
|divalent inorganic cation transport|
|monovalent inorganic cation transport|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of system process|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|endoplasmic reticulum|
|chemical homeostasis|
|transmembrane transport|
|ion transport|
|ATP binding|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-4.64|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.05|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.91|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|1.72|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7176
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP2A3 Expression in NALM6 Cells: 9.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>