ATP2C1 [The Human Chemical-Genetic Interaction Map Project]

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======= ATP2C1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP2C1
  * **<color #00a2e8>Official Name</color>**: ATPase secretory pathway Ca2+ transporting 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27032|27032]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P98194|P98194]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP2C1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP2C1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604384|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hydrolase|
|Cation ATPase N|
|E1-E2 ATPase|
|HAD|
|Cation ATPase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi calcium ion homeostasis|
|Golgi calcium ion transport|
|manganese transmembrane transporter activity, phosphorylative mechanism|
|manganese ion transmembrane transport|
|calcium transmembrane transporter activity, phosphorylative mechanism|
|manganese ion transport|
|proton-exporting ATPase activity, phosphorylative mechanism|
|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|
|actin cytoskeleton reorganization|
|transition metal ion transport|
|proton transmembrane transport|
|trans-Golgi network|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|calcium ion transmembrane transport|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|calcium ion transport|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|divalent metal ion transport|
|divalent inorganic cation transport|
|monovalent inorganic cation transport|
|epidermis development|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|actin cytoskeleton organization|
|cell-cell adhesion|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|actin filament-based process|
|cation transmembrane transport|
|Golgi membrane|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|cell adhesion|
|biological adhesion|
|ion transmembrane transport|
|Golgi apparatus|
|positive regulation of intracellular signal transduction|
|cytoskeleton organization|
|chemical homeostasis|
|transmembrane transport|
|ion transport|
|ATP binding|
|homeostatic process|
|positive regulation of signal transduction|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.76|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.92|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.73|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.71|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.71|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.7|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.75|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.85|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.87|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.01|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.18|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.28|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|3.16|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|4.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tmem165|TMEM165]]|0.606|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1921
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP2C1 Expression in NALM6 Cells: 6.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>