ATP5C1 [The Human Chemical-Genetic Interaction Map Project]

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======= ATP5C1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP5F1C
  * **<color #00a2e8>Official Name</color>**: ATP synthase F1 subunit gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=509|509]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P36542|P36542]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP5C1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP5C1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/108729|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-synt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)|
|proton-transporting ATP synthase activity, rotational mechanism|
|mitochondrial proton-transporting ATP synthase complex|
|mitochondrial ATP synthesis coupled proton transport|
|ATP synthesis coupled proton transport|
|energy coupled proton transport, down electrochemical gradient|
|cristae formation|
|ATP biosynthetic process|
|inner mitochondrial membrane organization|
|purine ribonucleoside triphosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate biosynthetic process|
|purine ribonucleoside triphosphate metabolic process|
|transmembrane transporter activity|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|nucleoside triphosphate metabolic process|
|mitochondrial transmembrane transport|
|oxidative phosphorylation|
|mitochondrial membrane organization|
|proton transmembrane transport|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|ATP metabolic process|
|mitochondrial transport|
|ATPase activity|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|drug metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|carbohydrate derivative biosynthetic process|
|inorganic ion transmembrane transport|
|cation transport|
|membrane organization|
|organophosphate metabolic process|
|ion transmembrane transport|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|ion transport|
|RNA binding|
|organonitrogen compound biosynthetic process|
|intracellular transport|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|establishment of localization in cell|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.73|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.73|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.74|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.79|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.82|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.83|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.86|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.91|
|[[:results:exp539|42°C R08 exp539]]|1.93|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.96|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.99|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|2|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.01|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.02|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.26|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.27|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.33|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.36|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.44|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.56|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.71|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.85|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|3|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|3.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp5a1|ATP5A1]]|0.693|
|[[:human genes:a:atp5b|ATP5B]]|0.693|
|[[:human genes:a:atp5d|ATP5D]]|0.69|
|[[:human genes:a:atp5o|ATP5O]]|0.687|
|[[:human genes:a:atp5e|ATP5E]]|0.6|
|[[:human genes:m:mrpl21|MRPL21]]|0.595|
|[[:human genes:s:selrc1|SELRC1]]|0.581|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.578|
|[[:human genes:a:atp5f1|ATP5F1]]|0.561|
|[[:human genes:t:tmem242|TMEM242]]|0.56|
|[[:human genes:w:wbscr16|WBSCR16]]|0.556|
|[[:human genes:s:sco2|SCO2]]|0.555|
|[[:human genes:a:atp5l|ATP5L]]|0.552|
|[[:human genes:d:dap3|DAP3]]|0.55|
|[[:human genes:s:slc25a26|SLC25A26]]|0.549|
|[[:human genes:a:atp5i|ATP5I]]|0.543|
|[[:human genes:g:gfm1|GFM1]]|0.541|
|[[:human genes:l:lars2|LARS2]]|0.541|
|[[:human genes:p:pars2|PARS2]]|0.535|
|[[:human genes:b:bcs1l|BCS1L]]|0.534|
|[[:human genes:a:atp5j|ATP5J]]|0.53|
|[[:human genes:n:nars2|NARS2]]|0.527|
|[[:human genes:a:atp5h|ATP5H]]|0.527|
|[[:human genes:m:mrpl45|MRPL45]]|0.524|
|[[:human genes:y:yars2|YARS2]]|0.52|
|[[:human genes:m:mrpl47|MRPL47]]|0.518|
|[[:human genes:m:mrps14|MRPS14]]|0.517|
|[[:human genes:n:ndufa1|NDUFA1]]|0.516|
|[[:human genes:r:rpusd4|RPUSD4]]|0.512|
|[[:human genes:q:qrsl1|QRSL1]]|0.508|
|[[:human genes:m:mrps25|MRPS25]]|0.508|
|[[:human genes:d:dars2|DARS2]]|0.508|
|[[:human genes:t:tufm|TUFM]]|0.507|
|[[:human genes:t:tars2|TARS2]]|0.506|
|[[:human genes:m:mrp63|MRP63]]|0.506|
|[[:human genes:m:mrps2|MRPS2]]|0.502|
|[[:human genes:p:pnpt1|PNPT1]]|0.5|
|[[:human genes:m:mrpl20|MRPL20]]|0.498|
|[[:human genes:a:atp5j2|ATP5J2]]|0.498|
|[[:human genes:e:ears2|EARS2]]|0.496|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.495|
|[[:human genes:g:gatc|GATC]]|0.495|
|[[:human genes:n:ndufc2|NDUFC2]]|0.494|
|[[:human genes:m:mrpl23|MRPL23]]|0.494|
|[[:human genes:f:fastkd5|FASTKD5]]|0.494|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.488|
|[[:human genes:c:cox16|COX16]]|0.485|
|[[:human genes:m:mrps6|MRPS6]]|0.485|
|[[:human genes:m:mars2|MARS2]]|0.484|
|[[:human genes:m:mrps34|MRPS34]]|0.483|
|[[:human genes:c:c10orf2|C10orf2]]|0.481|
|[[:human genes:m:mrps21|MRPS21]]|0.479|
|[[:human genes:v:vars2|VARS2]]|0.478|
|[[:human genes:n:ndufa3|NDUFA3]]|0.476|
|[[:human genes:r:rars2|RARS2]]|0.473|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.472|
|[[:human genes:n:ndufb11|NDUFB11]]|0.47|
|[[:human genes:s:sars2|SARS2]]|0.468|
|[[:human genes:n:ndufb5|NDUFB5]]|0.468|
|[[:human genes:m:mrps5|MRPS5]]|0.466|
|[[:human genes:n:ndufa2|NDUFA2]]|0.466|
|[[:human genes:o:opa1|OPA1]]|0.464|
|[[:human genes:h:hars2|HARS2]]|0.463|
|[[:human genes:m:mrps33|MRPS33]]|0.46|
|[[:human genes:m:mrps26|MRPS26]]|0.46|
|[[:human genes:t:triap1|TRIAP1]]|0.458|
|[[:human genes:e:elac2|ELAC2]]|0.458|
|[[:human genes:c:coa3|COA3]]|0.457|
|[[:human genes:f:fh|FH]]|0.457|
|[[:human genes:c:cox15|COX15]]|0.457|
|[[:human genes:m:mrps16|MRPS16]]|0.457|
|[[:human genes:d:dnlz|DNLZ]]|0.452|
|[[:human genes:n:ndufb3|NDUFB3]]|0.451|
|[[:human genes:s:slc25a3|SLC25A3]]|0.45|
|[[:human genes:c:cox7b|COX7B]]|0.45|
|[[:human genes:f:ftsj2|FTSJ2]]|0.449|
|[[:human genes:p:pmm2|PMM2]]|0.449|
|[[:human genes:p:pgm3|PGM3]]|0.448|
|[[:human genes:m:mrps18a|MRPS18A]]|0.446|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.445|
|[[:human genes:m:mbtps2|MBTPS2]]|0.443|
|[[:human genes:r:rbfa|RBFA]]|0.442|
|[[:human genes:a:alg6|ALG6]]|0.442|
|[[:human genes:g:gfm2|GFM2]]|0.439|
|[[:human genes:f:fars2|FARS2]]|0.439|
|[[:human genes:d:dhrsx|DHRSX]]|0.435|
|[[:human genes:m:mrpl15|MRPL15]]|0.435|
|[[:human genes:r:rpusd3|RPUSD3]]|0.434|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.434|
|[[:human genes:s:slc25a19|SLC25A19]]|0.434|
|[[:human genes:m:mrpl53|MRPL53]]|0.433|
|[[:human genes:m:mterfd1|MTERFD1]]|0.433|
|[[:human genes:t:tamm41|TAMM41]]|0.432|
|[[:human genes:p:pet112|PET112]]|0.428|
|[[:human genes:m:mrpl3|MRPL3]]|0.426|
|[[:human genes:c:c12orf65|C12orf65]]|0.426|
|[[:human genes:m:mtg1|MTG1]]|0.426|
|[[:human genes:d:dolk|DOLK]]|0.424|
|[[:human genes:m:mrpl44|MRPL44]]|0.422|
|[[:human genes:s:slc25a52|SLC25A52]]|0.422|
|[[:human genes:u:ube2g2|UBE2G2]]|0.421|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.42|
|[[:human genes:p:pdss1|PDSS1]]|0.419|
|[[:human genes:h:higd2a|HIGD2A]]|0.418|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.415|
|[[:human genes:m:mrps23|MRPS23]]|0.414|
|[[:human genes:c:crls1|CRLS1]]|0.413|
|[[:human genes:h:hccs|HCCS]]|0.413|
|[[:human genes:t:taz|TAZ]]|0.413|
|[[:human genes:c:c17orf89|C17orf89]]|0.411|
|[[:human genes:a:aifm1|AIFM1]]|0.411|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.41|
|[[:human genes:n:ndufb9|NDUFB9]]|0.41|
|[[:human genes:m:mrpl12|MRPL12]]|0.409|
|[[:human genes:a:aars2|AARS2]]|0.409|
|[[:human genes:n:ndufs2|NDUFS2]]|0.408|
|[[:human genes:t:tfb1m|TFB1M]]|0.408|
|[[:human genes:n:ndufv1|NDUFV1]]|0.407|
|[[:human genes:c:cycs|CYCS]]|0.407|
|[[:human genes:m:mrps9|MRPS9]]|0.407|
|[[:human genes:m:mrps11|MRPS11]]|0.407|
|[[:human genes:c:coa5|COA5]]|0.404|
|[[:human genes:p:pet117|PET117]]|0.403|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.403|
|[[:human genes:s:sec62|SEC62]]|0.403|
|[[:human genes:n:ndufs1|NDUFS1]]|0.402|
|[[:human genes:v:vezt|VEZT]]|0.401|
|[[:human genes:d:dohh|DOHH]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 77/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|2/26|
|breast|3/33|
|central nervous system|6/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|2/21|
|liver|4/20|
|lung|15/75|
|lymphocyte|1/16|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1519
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP5C1 Expression in NALM6 Cells: 6.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>