ATP6V1B1 [The Human Chemical-Genetic Interaction Map Project]

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======= ATP6V1B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP6V1B1
  * **<color #00a2e8>Official Name</color>**: ATPase H+ transporting V1 subunit B1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=525|525]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15313|P15313]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP6V1B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP6V1B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/192132|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-synt ab N|
|ATP-synt ab C|
|ATP-synt ab|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|renal sodium excretion|
|extrinsic component of synaptic vesicle membrane|
|renal sodium ion transport|
|proton-transporting V-type ATPase, V1 domain|
|olfactory behavior|
|proton transmembrane transporter activity|
|vacuolar proton-transporting V-type ATPase complex|
|chloride ion homeostasis|
|chemosensory behavior|
|monovalent inorganic anion homeostasis|
|phagosome acidification|
|potassium ion homeostasis|
|sodium ion homeostasis|
|prostanoid metabolic process|
|prostaglandin metabolic process|
|renal water homeostasis|
|transferrin transport|
|excretion|
|phagosome maturation|
|intracellular pH reduction|
|pH reduction|
|lateral plasma membrane|
|anion homeostasis|
|microvillus|
|multicellular organismal water homeostasis|
|iron ion transport|
|water homeostasis|
|hydrolase activity|
|regulation of intracellular pH|
|insulin receptor signaling pathway|
|regulation of cellular pH|
|inner ear morphogenesis|
|regulation of pH|
|unsaturated fatty acid metabolic process|
|cellular monovalent inorganic cation homeostasis|
|renal system process|
|icosanoid metabolic process|
|ear morphogenesis|
|transition metal ion transport|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|adult behavior|
|sensory perception of sound|
|sodium ion transport|
|cellular response to insulin stimulus|
|fatty acid derivative metabolic process|
|sensory perception of mechanical stimulus|
|regulation of macroautophagy|
|inner ear development|
|basolateral plasma membrane|
|ATP metabolic process|
|ear development|
|response to insulin|
|sensory organ morphogenesis|
|ossification|
|protein-containing complex binding|
|cellular response to peptide hormone stimulus|
|embryonic organ morphogenesis|
|apical plasma membrane|
|fatty acid metabolic process|
|multicellular organismal homeostasis|
|cellular response to peptide|
|regulation of autophagy|
|response to peptide hormone|
|monovalent inorganic cation transport|
|embryonic organ development|
|calcium ion homeostasis|
|response to peptide|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|monocarboxylic acid metabolic process|
|sensory organ development|
|inorganic cation transmembrane transport|
|embryonic morphogenesis|
|behavior|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|regulation of cellular catabolic process|
|cellular homeostasis|
|response to hormone|
|carboxylic acid metabolic process|
|ion transmembrane transport|
|cellular lipid metabolic process|
|animal organ morphogenesis|
|sensory perception|
|embryo development|
|regulation of catabolic process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|nervous system process|
|response to endogenous stimulus|
|ATP binding|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|small molecule metabolic process|
|nitrogen compound transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3680
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP6V1B1 Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>