ATP6V1D [The Human Chemical-Genetic Interaction Map Project]

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======= ATP6V1D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP6V1D
  * **<color #00a2e8>Official Name</color>**: ATPase H+ transporting V1 subunit D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51382|51382]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5K8|Q9Y5K8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP6V1D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP6V1D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609398|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. {ECO:0000250, ECO:0000269|PubMed:21844891}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-synt D|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proton-transporting V-type ATPase complex|
|proton-transporting ATPase activity, rotational mechanism|
|phagosome acidification|
|transferrin transport|
|phagosome maturation|
|intracellular pH reduction|
|protein localization to cilium|
|pH reduction|
|ATPase-coupled transmembrane transporter activity|
|iron ion transport|
|regulation of intracellular pH|
|insulin receptor signaling pathway|
|regulation of cellular pH|
|specific granule membrane|
|regulation of pH|
|cellular monovalent inorganic cation homeostasis|
|transition metal ion transport|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|cellular response to insulin stimulus|
|regulation of macroautophagy|
|cilium|
|response to insulin|
|cellular response to peptide hormone stimulus|
|lysosomal membrane|
|cellular response to peptide|
|regulation of autophagy|
|cilium assembly|
|cilium organization|
|response to peptide hormone|
|monovalent inorganic cation transport|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|response to peptide|
|neutrophil degranulation|
|centrosome|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|inorganic cation transmembrane transport|
|myeloid leukocyte activation|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|regulated exocytosis|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|protein localization to organelle|
|cellular chemical homeostasis|
|organelle assembly|
|leukocyte mediated immunity|
|ion homeostasis|
|exocytosis|
|cation transport|
|regulation of cellular catabolic process|
|cellular homeostasis|
|response to hormone|
|leukocyte activation|
|ion transmembrane transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|secretion by cell|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|chemical homeostasis|
|secretion|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|nitrogen compound transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-3.05|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.45|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.41|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.3|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.23|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-2.23|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.15|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.12|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-2.08|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-2.08|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.02|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.01|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.95|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.93|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.88|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-1.87|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.86|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.84|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.83|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.77|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.77|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.76|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.72|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.72|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.72|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.452|
|[[:human genes:a:atp6v0a2|ATP6V0A2]]|0.447|
|[[:human genes:p:prim1|PRIM1]]|0.441|
|[[:human genes:p:polr2j3|POLR2J3]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 108/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|3/28|
|bone|3/26|
|breast|4/33|
|central nervous system|3/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|7/21|
|liver|4/20|
|lung|8/75|
|lymphocyte|0/16|
|ovary|7/26|
|pancreas|5/24|
|peripheral nervous system|3/16|
|plasma cell|6/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|2/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 960
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP6V1D Expression in NALM6 Cells: 4.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>