ATP6V1E1 [The Human Chemical-Genetic Interaction Map Project]

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======= ATP6V1E1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP6V1E1
  * **<color #00a2e8>Official Name</color>**: ATPase H+ transporting V1 subunit E1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=529|529]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P36543|P36543]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP6V1E1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP6V1E1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/108746|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|vATP-synt E|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proton-transporting two-sector ATPase complex, catalytic domain|
|proton-transporting two-sector ATPase complex|
|proton-exporting ATPase activity, phosphorylative mechanism|
|proton-transporting ATPase activity, rotational mechanism|
|phagosome acidification|
|transferrin transport|
|phagosome maturation|
|intracellular pH reduction|
|pH reduction|
|microvillus|
|iron ion transport|
|hydrolase activity|
|ATPase binding|
|regulation of intracellular pH|
|insulin receptor signaling pathway|
|regulation of cellular pH|
|regulation of pH|
|cellular monovalent inorganic cation homeostasis|
|transition metal ion transport|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|cellular response to insulin stimulus|
|regulation of macroautophagy|
|response to insulin|
|cellular response to peptide hormone stimulus|
|endosome|
|lysosomal membrane|
|apical plasma membrane|
|cellular response to peptide|
|regulation of autophagy|
|response to peptide hormone|
|monovalent inorganic cation transport|
|response to peptide|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|inorganic cation transmembrane transport|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|regulation of cellular catabolic process|
|cellular homeostasis|
|response to hormone|
|ion transmembrane transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.46|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.13|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.06|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.05|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.91|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.88|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.86|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.84|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.74|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.603|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.479|
|[[:human genes:p:prim1|PRIM1]]|0.444|
|[[:human genes:t:trappc11|TRAPPC11]]|0.419|
|[[:human genes:v:vps28|VPS28]]|0.415|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.408|
|[[:human genes:r:rbm48|RBM48]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 479/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|20/28|
|blood|19/28|
|bone|20/26|
|breast|22/33|
|central nervous system|33/56|
|cervix|2/4|
|colorectal|15/17|
|esophagus|4/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|15/21|
|liver|11/20|
|lung|45/75|
|lymphocyte|12/16|
|ovary|21/26|
|pancreas|15/24|
|peripheral nervous system|8/16|
|plasma cell|13/15|
|prostate|0/1|
|skin|14/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|14/22|
|urinary tract|18/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1073
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP6V1E1 Expression in NALM6 Cells: 5.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>