ATP6V1H [The Human Chemical-Genetic Interaction Map Project]

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======= ATP6V1H =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP6V1H
  * **<color #00a2e8>Official Name</color>**: ATPase H+ transporting V1 subunit H
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51606|51606]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UI12|Q9UI12]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP6V1H&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP6V1H|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608861|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-ATPase H C|
|V-ATPase H N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vacuolar proton-transporting V-type ATPase, V1 domain|
|enzyme regulator activity|
|vacuolar acidification|
|proton-transporting ATPase activity, rotational mechanism|
|phagosome acidification|
|regulation of defense response to virus by virus|
|transferrin transport|
|phagosome maturation|
|intracellular pH reduction|
|pH reduction|
|iron ion transport|
|regulation of intracellular pH|
|insulin receptor signaling pathway|
|regulation of cellular pH|
|regulation of pH|
|cellular monovalent inorganic cation homeostasis|
|transition metal ion transport|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|cellular response to insulin stimulus|
|regulation of macroautophagy|
|response to insulin|
|ATPase activity|
|cellular response to peptide hormone stimulus|
|lysosomal membrane|
|cellular response to peptide|
|regulation of autophagy|
|response to peptide hormone|
|monovalent inorganic cation transport|
|response to peptide|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|endocytosis|
|inorganic cation transmembrane transport|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|import into cell|
|viral process|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|symbiotic process|
|ion homeostasis|
|interspecies interaction between organisms|
|cation transport|
|regulation of cellular catabolic process|
|cellular homeostasis|
|response to hormone|
|ion transmembrane transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-2.39|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.29|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.17|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.16|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.05|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.99|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.89|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.89|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.86|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.85|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.83|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.82|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.82|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.79|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.448|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.431|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 57/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|0/28|
|bone|1/26|
|breast|3/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|2/20|
|lung|7/75|
|lymphocyte|1/16|
|ovary|5/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|2/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2148
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP6V1H Expression in NALM6 Cells: 4.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>