ATXN10 [The Human Chemical-Genetic Interaction Map Project]

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======= ATXN10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATXN10
  * **<color #00a2e8>Official Name</color>**: ataxin 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25814|25814]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBB4|Q9UBB4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATXN10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATXN10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611150|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Atx10homo assoc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein homotrimerization|
|protein trimerization|
|protein homooligomerization|
|cilium assembly|
|enzyme binding|
|cilium organization|
|neuronal cell body|
|dendrite|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|protein complex oligomerization|
|neuron projection development|
|perinuclear region of cytoplasm|
|organelle assembly|
|neuron development|
|neuron differentiation|
|identical protein binding|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|generation of neurons|
|protein-containing complex assembly|
|extracellular space|
|neurogenesis|
|cell development|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-2.15|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.98|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.86|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.82|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.81|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.8|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.79|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.79|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.72|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.73|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.87|
|[[:results:exp539|42°C R08 exp539]]|1.9|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.742|
|[[:human genes:d:dpagt1|DPAGT1]]|0.721|
|[[:human genes:a:alg1|ALG1]]|0.686|
|[[:human genes:v:vezt|VEZT]]|0.671|
|[[:human genes:p:pmm2|PMM2]]|0.661|
|[[:human genes:t:triap1|TRIAP1]]|0.628|
|[[:human genes:g:gmppb|GMPPB]]|0.627|
|[[:human genes:u:uap1|UAP1]]|0.615|
|[[:human genes:p:ppcs|PPCS]]|0.612|
|[[:human genes:g:gfpt1|GFPT1]]|0.612|
|[[:human genes:r:rtcb|RTCB]]|0.611|
|[[:human genes:d:dohh|DOHH]]|0.606|
|[[:human genes:a:adsl|ADSL]]|0.606|
|[[:human genes:r:rpia|RPIA]]|0.602|
|[[:human genes:s:srp14|SRP14]]|0.597|
|[[:human genes:t:ttc4|TTC4]]|0.59|
|[[:human genes:g:gemin6|GEMIN6]]|0.587|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.583|
|[[:human genes:f:fh|FH]]|0.581|
|[[:human genes:o:oraov1|ORAOV1]]|0.576|
|[[:human genes:a:atic|ATIC]]|0.572|
|[[:human genes:r:rnmt|RNMT]]|0.572|
|[[:human genes:a:alg13|ALG13]]|0.571|
|[[:human genes:g:gemin8|GEMIN8]]|0.569|
|[[:human genes:e:elac2|ELAC2]]|0.561|
|[[:human genes:s:srd5a3|SRD5A3]]|0.561|
|[[:human genes:r:rpp21|RPP21]]|0.56|
|[[:human genes:u:uhrf1|UHRF1]]|0.559|
|[[:human genes:d:dolk|DOLK]]|0.555|
|[[:human genes:m:med4|MED4]]|0.554|
|[[:human genes:z:zrsr2|ZRSR2]]|0.554|
|[[:human genes:s:slc25a26|SLC25A26]]|0.553|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.553|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.552|
|[[:human genes:m:med16|MED16]]|0.55|
|[[:human genes:r:rptor|RPTOR]]|0.549|
|[[:human genes:d:dr1|DR1]]|0.548|
|[[:human genes:r:rfk|RFK]]|0.545|
|[[:human genes:s:slc25a19|SLC25A19]]|0.543|
|[[:human genes:t:trmt5|TRMT5]]|0.543|
|[[:human genes:a:alg2|ALG2]]|0.539|
|[[:human genes:r:rpe|RPE]]|0.538|
|[[:human genes:p:ppa2|PPA2]]|0.536|
|[[:human genes:a:atp5j|ATP5J]]|0.535|
|[[:human genes:t:tsen54|TSEN54]]|0.535|
|[[:human genes:r:rft1|RFT1]]|0.533|
|[[:human genes:p:pelo|PELO]]|0.531|
|[[:human genes:m:mbtps2|MBTPS2]]|0.529|
|[[:human genes:t:ten1|TEN1]]|0.528|
|[[:human genes:t:tbca|TBCA]]|0.527|
|[[:human genes:d:dhps|DHPS]]|0.525|
|[[:human genes:e:eef1e1|EEF1E1]]|0.524|
|[[:human genes:t:tprkb|TPRKB]]|0.524|
|[[:human genes:e:elp2|ELP2]]|0.523|
|[[:human genes:e:exoc4|EXOC4]]|0.522|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.521|
|[[:human genes:r:rabggtb|RABGGTB]]|0.521|
|[[:human genes:l:lsm11|LSM11]]|0.519|
|[[:human genes:t:trnt1|TRNT1]]|0.517|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.517|
|[[:human genes:d:dhrsx|DHRSX]]|0.515|
|[[:human genes:e:eny2|ENY2]]|0.514|
|[[:human genes:a:alg5|ALG5]]|0.514|
|[[:human genes:t:tpk1|TPK1]]|0.514|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.512|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.511|
|[[:human genes:u:uxt|UXT]]|0.51|
|[[:human genes:p:ppp6c|PPP6C]]|0.507|
|[[:human genes:b:bcs1l|BCS1L]]|0.507|
|[[:human genes:r:romo1|ROMO1]]|0.503|
|[[:human genes:a:atp2a2|ATP2A2]]|0.502|
|[[:human genes:u:urm1|URM1]]|0.501|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.498|
|[[:human genes:l:lsm10|LSM10]]|0.498|
|[[:human genes:n:nae1|NAE1]]|0.498|
|[[:human genes:o:osgep|OSGEP]]|0.498|
|[[:human genes:h:hccs|HCCS]]|0.497|
|[[:human genes:h:haus8|HAUS8]]|0.496|
|[[:human genes:a:atp5b|ATP5B]]|0.494|
|[[:human genes:t:tti1|TTI1]]|0.493|
|[[:human genes:t:tamm41|TAMM41]]|0.493|
|[[:human genes:y:yars|YARS]]|0.493|
|[[:human genes:g:gemin7|GEMIN7]]|0.491|
|[[:human genes:c:cep57|CEP57]]|0.489|
|[[:human genes:d:dpf2|DPF2]]|0.488|
|[[:human genes:t:telo2|TELO2]]|0.487|
|[[:human genes:t:tgs1|TGS1]]|0.486|
|[[:human genes:b:bap1|BAP1]]|0.485|
|[[:human genes:t:trmt10a|TRMT10A]]|0.483|
|[[:human genes:n:n6amt1|N6AMT1]]|0.483|
|[[:human genes:e:elp3|ELP3]]|0.483|
|[[:human genes:a:alg14|ALG14]]|0.482|
|[[:human genes:d:ddx39a|DDX39A]]|0.482|
|[[:human genes:a:atp5o|ATP5O]]|0.481|
|[[:human genes:m:mrps33|MRPS33]]|0.479|
|[[:human genes:u:utp23|UTP23]]|0.478|
|[[:human genes:a:alg6|ALG6]]|0.478|
|[[:human genes:s:sec62|SEC62]]|0.478|
|[[:human genes:a:atp5a1|ATP5A1]]|0.478|
|[[:human genes:c:chchd4|CHCHD4]]|0.477|
|[[:human genes:t:tbcb|TBCB]]|0.477|
|[[:human genes:g:gnb1l|GNB1L]]|0.476|
|[[:human genes:e:eprs|EPRS]]|0.476|
|[[:human genes:t:tmem41b|TMEM41B]]|0.475|
|[[:human genes:w:wdr59|WDR59]]|0.475|
|[[:human genes:d:dars2|DARS2]]|0.475|
|[[:human genes:m:mrps16|MRPS16]]|0.475|
|[[:human genes:p:ppp4c|PPP4C]]|0.474|
|[[:human genes:u:uba3|UBA3]]|0.473|
|[[:human genes:d:ddx1|DDX1]]|0.473|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.472|
|[[:human genes:n:nbn|NBN]]|0.471|
|[[:human genes:y:yars2|YARS2]]|0.47|
|[[:human genes:p:pggt1b|PGGT1B]]|0.47|
|[[:human genes:c:c15orf41|C15orf41]]|0.467|
|[[:human genes:t:txnrd1|TXNRD1]]|0.467|
|[[:human genes:w:wdr92|WDR92]]|0.466|
|[[:human genes:m:mrps6|MRPS6]]|0.466|
|[[:human genes:r:rbfa|RBFA]]|0.466|
|[[:human genes:t:tti2|TTI2]]|0.466|
|[[:human genes:o:oip5|OIP5]]|0.465|
|[[:human genes:f:fnta|FNTA]]|0.464|
|[[:human genes:d:ddx20|DDX20]]|0.462|
|[[:human genes:a:aars|AARS]]|0.462|
|[[:human genes:t:tsen34|TSEN34]]|0.462|
|[[:human genes:s:srprb|SRPRB]]|0.462|
|[[:human genes:p:pgm3|PGM3]]|0.461|
|[[:human genes:m:mrps14|MRPS14]]|0.46|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.459|
|[[:human genes:a:apaf1|APAF1]]|0.458|
|[[:human genes:g:gpn2|GPN2]]|0.458|
|[[:human genes:c:c17orf89|C17orf89]]|0.456|
|[[:human genes:u:uso1|USO1]]|0.456|
|[[:human genes:h:hspd1|HSPD1]]|0.456|
|[[:human genes:d:dctn6|DCTN6]]|0.456|
|[[:human genes:d:dnlz|DNLZ]]|0.455|
|[[:human genes:t:trmt61a|TRMT61A]]|0.452|
|[[:human genes:t:taz|TAZ]]|0.452|
|[[:human genes:g:gclc|GCLC]]|0.452|
|[[:human genes:g:gfer|GFER]]|0.452|
|[[:human genes:e:eif3f|EIF3F]]|0.452|
|[[:human genes:s:ssb|SSB]]|0.452|
|[[:human genes:c:cox16|COX16]]|0.451|
|[[:human genes:m:mrps11|MRPS11]]|0.45|
|[[:human genes:n:nars|NARS]]|0.446|
|[[:human genes:p:pam16|PAM16]]|0.445|
|[[:human genes:g:gtf3c5|GTF3C5]]|0.445|
|[[:human genes:k:kdsr|KDSR]]|0.445|
|[[:human genes:r:rad50|RAD50]]|0.444|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.444|
|[[:human genes:z:zcrb1|ZCRB1]]|0.442|
|[[:human genes:p:ppcdc|PPCDC]]|0.441|
|[[:human genes:c:ctc1|CTC1]]|0.441|
|[[:human genes:t:tomm22|TOMM22]]|0.441|
|[[:human genes:u:ube2g2|UBE2G2]]|0.439|
|[[:human genes:m:mrpl21|MRPL21]]|0.439|
|[[:human genes:s:sdha|SDHA]]|0.438|
|[[:human genes:g:gatc|GATC]]|0.437|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.436|
|[[:human genes:m:mrpl23|MRPL23]]|0.436|
|[[:human genes:w:wdr24|WDR24]]|0.436|
|[[:human genes:t:txnl4b|TXNL4B]]|0.436|
|[[:human genes:g:gemin5|GEMIN5]]|0.435|
|[[:human genes:d:dad1|DAD1]]|0.435|
|[[:human genes:u:uba5|UBA5]]|0.434|
|[[:human genes:c:crls1|CRLS1]]|0.434|
|[[:human genes:m:mrps5|MRPS5]]|0.434|
|[[:human genes:b:bak1|BAK1]]|0.434|
|[[:human genes:c:cox5a|COX5A]]|0.434|
|[[:human genes:c:ccdc101|CCDC101]]|0.433|
|[[:human genes:s:sec61g|SEC61G]]|0.433|
|[[:human genes:a:atp5d|ATP5D]]|0.433|
|[[:human genes:e:exoc3|EXOC3]]|0.432|
|[[:human genes:s:srp68|SRP68]]|0.432|
|[[:human genes:c:c14orf80|C14orf80]]|0.432|
|[[:human genes:m:mis18a|MIS18A]]|0.432|
|[[:human genes:m:mrpl27|MRPL27]]|0.432|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.431|
|[[:human genes:p:pgs1|PGS1]]|0.431|
|[[:human genes:t:tkt|TKT]]|0.431|
|[[:human genes:x:xrcc3|XRCC3]]|0.431|
|[[:human genes:r:rad1|RAD1]]|0.429|
|[[:human genes:n:nsmce1|NSMCE1]]|0.429|
|[[:human genes:m:mocs3|MOCS3]]|0.429|
|[[:human genes:t:thoc6|THOC6]]|0.427|
|[[:human genes:w:wbscr16|WBSCR16]]|0.427|
|[[:human genes:s:sars2|SARS2]]|0.427|
|[[:human genes:w:wdr82|WDR82]]|0.427|
|[[:human genes:r:rpusd4|RPUSD4]]|0.427|
|[[:human genes:g:gfm1|GFM1]]|0.425|
|[[:human genes:c:casp9|CASP9]]|0.424|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.423|
|[[:human genes:c:cbfb|CBFB]]|0.423|
|[[:human genes:b:bub3|BUB3]]|0.421|
|[[:human genes:t:tufm|TUFM]]|0.421|
|[[:human genes:e:eftud1|EFTUD1]]|0.421|
|[[:human genes:c:c14orf166|C14orf166]]|0.421|
|[[:human genes:a:alg8|ALG8]]|0.421|
|[[:human genes:p:polr3h|POLR3H]]|0.42|
|[[:human genes:c:cox17|COX17]]|0.418|
|[[:human genes:p:pik3r4|PIK3R4]]|0.417|
|[[:human genes:c:crcp|CRCP]]|0.417|
|[[:human genes:t:tmem242|TMEM242]]|0.416|
|[[:human genes:e:elp6|ELP6]]|0.416|
|[[:human genes:a:atp5h|ATP5H]]|0.416|
|[[:human genes:c:cct7|CCT7]]|0.415|
|[[:human genes:l:lmo2|LMO2]]|0.414|
|[[:human genes:c:cdipt|CDIPT]]|0.413|
|[[:human genes:p:pdap1|PDAP1]]|0.413|
|[[:human genes:d:dap3|DAP3]]|0.413|
|[[:human genes:m:mrps34|MRPS34]]|0.412|
|[[:human genes:c:csnk2b|CSNK2B]]|0.412|
|[[:human genes:t:tubd1|TUBD1]]|0.412|
|[[:human genes:m:mrps18a|MRPS18A]]|0.412|
|[[:human genes:n:ndufb5|NDUFB5]]|0.411|
|[[:human genes:t:timm22|TIMM22]]|0.411|
|[[:human genes:c:cept1|CEPT1]]|0.411|
|[[:human genes:c:cycs|CYCS]]|0.41|
|[[:human genes:s:snapc5|SNAPC5]]|0.41|
|[[:human genes:m:med25|MED25]]|0.41|
|[[:human genes:t:tpi1|TPI1]]|0.41|
|[[:human genes:r:rbmx2|RBMX2]]|0.409|
|[[:human genes:t:tbp|TBP]]|0.408|
|[[:human genes:s:srp72|SRP72]]|0.408|
|[[:human genes:p:pdss1|PDSS1]]|0.408|
|[[:human genes:g:gtf3a|GTF3A]]|0.407|
|[[:human genes:m:mrps21|MRPS21]]|0.406|
|[[:human genes:p:plaa|PLAA]]|0.406|
|[[:human genes:e:eif4e|EIF4E]]|0.405|
|[[:human genes:m:mrpl15|MRPL15]]|0.404|
|[[:human genes:p:paxip1|PAXIP1]]|0.404|
|[[:human genes:s:sco2|SCO2]]|0.403|
|[[:human genes:v:vrk1|VRK1]]|0.403|
|[[:human genes:c:cbx3|CBX3]]|0.402|
|[[:human genes:t:tube1|TUBE1]]|0.402|
|[[:human genes:t:timm13|TIMM13]]|0.402|
|[[:human genes:t:taf1a|TAF1A]]|0.402|
|[[:human genes:m:msto1|MSTO1]]|0.402|
|[[:human genes:t:timm10|TIMM10]]|0.401|
|[[:human genes:d:ddx55|DDX55]]|0.401|
|[[:human genes:e:ercc2|ERCC2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2469
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATXN10 Expression in NALM6 Cells: 6.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>